155431-06-4

Basic information

• Product Name: ethyl 4-hydroxy-3-oxo-4-phenylbutanoate
• Synonyms: ethyl 4-hydroxy-3-oxo-4-phenylbutanoate
• CAS NO: 155431-06-4
• Molecular Formula: C12H14O4
• Molecular Weight: 222.23716
• Mol File: 155431-06-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-hydroxy-3-oxo-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-3-oxo-4-phenylbutanoate(155431-06-4)
• EPA Substance Registry System: ethyl 4-hydroxy-3-oxo-4-phenylbutanoate(155431-06-4)

Safety Data

• Hazardous Substances Data: 155431-06-4(Hazardous Substances Data)

Upstream product

• 6270-17-3 ethyl 3-benzoylpropanoate 
• 1071-46-1 hydrogen ethyl malonate 
• 1074-12-0 phenylglyoxal hydrate 
• 288-36-8 1 ,2,3-Triazole 

Relevant articles and documents

Base-Controlled Reactions through an Aldol Intermediate Formed between 2-Oxoaldehydes and Malonate Half Esters

A practical, atom-economical, base-directed, and highly efficient method for the generation of different selective products through a common aldol intermediate of 2-oxoaldehydes and malonate half esters is successfully developed. The addition of a strong basic environment (potassium tert-butoxide) catalyzed the synthesis of stable decarboxylative aldol products (α-hydroxy ketones), while the Doebner modification procedure resulted in decarboxylative elimination to (E)-α,β-unsaturated esters in good yields. The application of this method in one pot and one pot/two steps with azoles helped to develop regioselective α- and β-azolated products in appreciable yields.

Catalytic oxidations of enolizable ketones using 2-alkylidene-4- oxothiazolidine vinyl bromide

Direct oxidation of enolizable ketones to α-hydroxy derivatives, vicinal dicarbonyls or tricarbonyl compounds has been achieved by a catalytic amount of 2-alkylidene-4-oxothiazolidine vinyl bromide in DMSO as a solvent. The yields range from moderate to good.

Cycloadditions with Alkoxynitrile Oxides, RO-CN+-O-, (Alkyl Cyanate N-Oxides)

Alkyl formhydroximates have been synthesized by reacting alkyl orthoesters with hydrogen sulfide followed by treatment of the alkyl thioformate formed with hydroxylamine.Chlorination of alkyl formhydroximates with N-chlorosuccinimide gives alkyl chlorofor