1557-31-9

Basic information

• Product Name: 4-benzyl-1-methyl-piperidine
• Synonyms: 4-benzyl-1-methyl-piperidine
• CAS NO: 1557-31-9
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.3
• Mol File: 1557-31-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 266.8°Cat760mmHg
• Flash Point: 105.3°C
• Appearance: /
• Density: 0.966g/cm³
• Vapor Pressure: 0.00844mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 4-benzyl-1-methyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-1-methyl-piperidine(1557-31-9)
• EPA Substance Registry System: 4-benzyl-1-methyl-piperidine(1557-31-9)

Safety Data

• Hazardous Substances Data: 1557-31-9(Hazardous Substances Data)

Usage

General Description

4-benzyl-1-methyl-piperidine is a chemical compound that belongs to the piperidine class of organic compounds. It is also known by the trade name Nuciferine and is commonly found in the plant species Nymphaea caerulea, also known as the blue lotus flower. 4-benzyl-1-methyl-piperidine has been studied for its potential medicinal properties, including its potential as a neuroprotective agent and its ability to modulate dopamine receptor activity. Additionally, 4-benzyl-1-methyl-piperidine has been investigated for its potential role in treating addiction and as a potential tool for studying the central nervous system. However, further research is needed to fully understand its pharmacological effects and potential therapeutic applications.

InChI:InChI=1/C13H19N/c1-14-9-7-13(8-10-14)11-12-5-3-2-4-6-12/h2-6,13H,7-11H2,1H3

Upstream product

• 100-52-7 benzaldehyde 
• 5519-50-6 1-methyl-3-piperidone 
• 2116-65-6 4-benzyl pyridine 
• 78815-42-6 4-benzyl-1-methylpyridinium iodide 
• 857523-25-2 4-(α-hydroxy-benzyl)-1-methyl-piperidin-3-one 
• 31252-42-3 4-benzylpyperidine 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 67-56-1 methanol 

Downstream Products

• 99878-55-4 4-benzyl-3-(4-benzyl-1-methyl-2-piperidyl)-1-methyl-1,2,3,4-tetrahydropyridine 
• 92040-00-1 (1-methylpiperidin-4-yl)(phenyl)methanone 
• 109262-02-4 4-benzyl-1,1-dimethyl-piperidinium; iodide 
• 21199-23-5 4-benzyl-1-methyl-1-(3-trimethylammonio-propyl)-piperidinium; dibromide 
• 6071-92-7 VUF 4589 

Relevant articles and documents

Methyl-Selective α-Oxygenation of Tertiary Amines to Formamides by Employing Copper/Moderately Hindered Nitroxyl Radical (DMN-AZADO or 1-Me-AZADO)

Methyl-selective α-oxygenation of tertiary amines is a highly attractive approach for synthesizing formamides while preserving the amine substrate skeletons. Therefore, the development of efficient catalysts that can advance regioselective α-oxygenation at the N-methyl positions using molecular oxygen (O2) as the terminal oxidant is an important subject. In this study, we successfully developed a highly regioselective and efficient aerobic methyl-selective α-oxygenation of tertiary amines by employing a Cu/nitroxyl radical catalyst system. The use of moderately hindered nitroxyl radicals, such as 1,5-dimethyl-9-azanoradamantane N-oxyl (DMN-AZADO) and 1-methyl-2-azaadamanane N-oxyl (1-Me-AZADO), was very important to promote the oxygenation effectively mainly because these N-oxyls have longer life-times than less hindered N-oxyls. Various types of tertiary N-methylamines were selectively converted to the corresponding formamides. A plausible reaction mechanism is also discussed on the basis of experimental evidence, together with DFT calculations. The high regioselectivity of this catalyst system stems from steric restriction of the amine-N-oxyl interactions.

Solid-phase synthesis of tertiary N-Methyl amines including tropanes

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A new route to dithiocarbamates from tertiary N-methyl and N-benzylamines

The sequential treatment of various tertiary N-methyl and N-benzylamines with carbon disulfide, and then with an alkyl halide in tetrahydrofuran gave the corresponding dithiocarbamates in good to excellent yields.