156185-63-6

Basic information

• Product Name: TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• Synonyms: 4-(3-HYDROXY-PROPYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-4-(3'-PROPANOL)-PIPERIDINE;TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;4-(3-Hydroxypropyl)piperidine, N-BOC protected;Tert-butyl 4-(3-hydroxypropyl)tetrahydro-1(2H)-pyridinecarboxylate ,97%;3-(1-Boc-4-piperidyl)-1-propanol;3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanol;3-(N-Boc-piperidin-4-yl)propanol
• CAS NO: 156185-63-6
• Molecular Formula: C₁₃H₂₅NO₃
• Molecular Weight: 243.34
• Product Categories: Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines;CMLLYL
• Mol File: 156185-63-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 339.8 °C at 760 mmHg
• Flash Point: 159.3 °C
• Appearance: /
• Density: 1.029
• Vapor Pressure: 6E-06mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: 2-8°C
• PKA: 15.16±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(156185-63-6)
• EPA Substance Registry System: TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(156185-63-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 156185-63-6(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is a chemical compound with the molecular formula C16H29NO3. It is a colorless liquid with a slight odor, and it is commonly used as an intermediate in the pharmaceutical industry for the production of certain medications. TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE is known to have various pharmacological properties, including being an inhibitor of cholinesterase activity, which makes it potentially valuable in the treatment of Alzheimer's disease. It also has the potential to be used in the synthesis of certain antihypertensive and antiarrhythmic drugs. Additionally, it has been used in the synthesis of other biologically active compounds and as a reagent in organic chemistry reactions.

InChI:InChI=1/C13H25NO3/c1-13(2,3)17-12(16)14-8-6-11(7-9-14)5-4-10-15/h11,15H,4-10H2,1-3H3

Upstream product

• 7037-49-2 3-(piperidin-4-yl)propan-1-ol 
• 34619-03-9 tert-butyldicarbonate 
• 165528-85-8 1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate 
• 162504-75-8 tert-butyl 4-(3-methoxy-3-oxopropyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109438-76-8 3-[4]piperidyl-propan-1-ol; toluene-4-sulfonate 
• 104-58-5 3-piperidinopropan-1-ol 
• 403802-41-5 tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 

Downstream Products

• 692890-07-6 methyl 3-(3-(N-Boc-piperidin-4-yl)-propoxy)-phenylacetate 
• 203306-85-8 tert-butyl 4-[3-(p-tolylsulfonyloxy)propyl]piperidine-1-carboxylate 
• 203859-94-3 4-(3-Methanesulfonyloxy-propyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1204301-92-7 4-[3-(4-methoxycarbonyl-3-methylphenoxy)propyl]piperidine-1-carboxylic acid tert-butyl ester 
• 1369390-39-5 [3-(1-{4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl}-piperidin-4-yl)-propyl]-trimethyl-ammonium trilfuoroacetate salt 
• 692890-13-4 3-(3-(N-Boc-piperidin-4-yl)-propoxy)-phenylacetic acid 
• 165528-85-8 1,1-dimethylethyl 4-(3-oxopropyl)-1-piperidinecarboxylate 
• 912362-37-9 C₂₉H₃₉F₂N₃O₄ 
• 873546-86-2 ethyl 4-{3-[4-(3-{4-[ethoxy(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzimidate 
• 873546-78-2 tert-butyl 4-[3-(4-cyanophenoxy)propyl]-1-piperidinecarboxylate 
• 873546-85-1 4-(3-{1-[3-(4-cyano-3-fluorophenoxy) propyl]-4-piperidinyl}propoxy)-2-fluorobenzonitrile 
• 873546-83-9 4-(3-{1-[3-(4-cyanophenoxy)propyl]-4-piperidinyl}propoxy)-2-fluorobenzonitrile 
• 873546-80-6 4-(3-{4-[3-(4-cyanophenoxy)propyl]-1-piperidinyl}propoxy)benzonitrile 
• 873546-82-8 2-fluoro-4-[3-(4-piperidinyl)propoxy] benzonitrile 

Relevant articles and documents

Catalyst-Free Deaminative Functionalizations of Primary Amines by Photoinduced Single-Electron Transfer

The use of pyridinium-activated primary amines as photoactive functional groups for deaminative generation of alkyl radicals under catalyst-free conditions is described. By taking advantage of the visible light absorptivity of electron donor–acceptor complexes between Katritzky pyridinium salts and either Hantzsch ester or Et3N, photoinduced single-electron transfer could be initiated in the absence of a photocatalyst. This general reactivity platform has been applied to deaminative alkylation (Giese), allylation, vinylation, alkynylation, thioetherification, and hydrodeamination reactions. The mild conditions are amenable to a diverse range of primary and secondary alkyl pyridiniums and demonstrate broad functional group tolerance.

NOVEL BENZODIOXANE-PIPERIDINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS FOR TREATING NEUROPSYCHIATRIC DISORDERS

The present invention concerns benzodioxane-piperidine with general formula I: wherein notably: R1 represents one or more identical or different substituent(s) on the benzene ring, each independently representing a hydrogen or halogen atom, or a C1-4 alkyl group, or a C1-4 alkoxy group or a C1-4 hydroxyalkyl group or a C1-4 alkylcarbonyl or an alkoxycarbonyl group or an OH group or an SO2R group with R alkyl, or a CN group, or a CF3 group, or an OCF 3 group; n=1, 2 or 3;m=0 or 1, andR2 represents one or more identical or different substituent(s) on the oxazolidinone or morpholinone ring, each independently representing: a hydrogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group, or a C1-4 hydroxyalkyl group, or an alkylcarbonyl group, or an alkoxycarbonyl group, or an alkoxyphenyl group.

[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases

The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.