157255-72-6Relevant articles and documents
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
Peng, Yi-Hui,Ueng, Shau-Hua,Tseng, Chen-Tso,Hung, Ming-Shiu,Song, Jen-Shin,Wu, Jian-Sung,Liao, Fang-Yu,Fan, Yu-Shiou,Wu, Mine-Hsine,Hsiao, Wen-Chi,Hsueh, Ching-Cheng,Lin, Shu-Yu,Cheng, Chia-Yi,Tu, Chih-Hsiang,Lee, Lung-Chun,Cheng, Ming-Fu,Shia, Kak-Shan,Shih, Chuan,Wu, Su-Ying
, p. 282 - 293 (2016)
Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors, is a therapeutic target for the cancer immunotherapy. A number of IDO1 inhibitors have been identified, but only limited structural biology studies of IDO1 inhibitors are available t
Direct synthesis of pyrroles via a silver-promoted three-component reaction involving unusual imidazole ring opening
Zeng, Jing,Bai, Yaguang,Cai, Shuting,Ma, Jimei,Liu, Xue-Wei
supporting information; experimental part, p. 12855 - 12857 (2012/02/03)
A novel silver-promoted three-component reaction toward the synthesis of multifunctionalized pyrroles has been developed. This reaction involves an unusual imidazole ring decomposition, presumably via 1,5-isomerization and subsequent hydrolysis.
Substituted inmidazoles as bombesin receptor subtype-3 modulators
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Page/Page column 27-28, (2010/02/17)
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.