157327-42-9Relevant articles and documents
Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin
Chen, Ping,Feng, Dennis,Qian, Xiaoxia,Apgar, James,Wilkening, Robert,Kuethe, Jeffrey T.,Gao, Ying-Duo,Scapin, Giovanna,Cox, Jason,Doss, George,Eiermann, George,He, Huaibing,Li, Xiaohua,Lyons, Kathryn A.,Metzger, Joseph,Petrov, Aleksandr,Wu, Joseph K.,Xu, Shiyao,Weber, Ann E.,Yan, Youwei,Roy, Ranabir Sinha,Biftu, Tesfaye
, p. 5767 - 5771 (2015)
A series of novel substituted-[(3R)-amino-2-(2,5-difluorophenyl)]tetrahydro-2H-pyran analogs have been prepared and evaluated as potent, selective and orally active DPP-4 inhibitors. These efforts lead to the discovery of a long acting DPP-4 inhibitor, omarigliptin (MK-3102), which recently completed phase III clinical development and has been approved in Japan.
Guanidine derivative and application thereof
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Paragraph 0534; 0536-0538, (2020/06/09)
The invention relates to a guanidine derivative serving as a VAP-1 inhibitor and application of the guanidine derivative, and further relates to a pharmaceutical composition containing the compound. The compound or the pharmaceutical composition can be us
Bicyclic inhibitors of histone deacetylase
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Page/Page column 14-15, (2018/05/04)
Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).