157373-08-5

Basic information

• Product Name: 2,3,4-TRIFLUOROBENZOYL CHLORIDE
• Synonyms: 2,3,4-TRIFLUOROBENZOYL CHLORIDE;2,3,4-Trifluorobenzoyl chloride, 97+%;Benzoyl chloride, 2,3,4-trifluoro- (9CI);2,3,4-Trifluorobenzoyl chloride 98%;2,3,4-Trifluorobenzoylchloride98%;TRIFLUOROBENZOYLCHLORIDE
• CAS NO: 157373-08-5
• Molecular Formula: C₇H₂ClF₃O
• Molecular Weight: 194.54
• Product Categories: ACIDHALIDE;Aromatics;Miscellaneous Reagents;Fluorine series
• Mol File: 157373-08-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 143-144 °C130 mm Hg(lit.)
• Flash Point: 199 °F
• Appearance: clear colorless to pale yellow liquid
• Density: 1.522 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: n20/D 1.497(lit.)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
• Sensitive: Lachrymatory
• BRN: 9122972
• CAS DataBase Reference: 2,3,4-TRIFLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIFLUOROBENZOYL CHLORIDE(157373-08-5)
• EPA Substance Registry System: 2,3,4-TRIFLUOROBENZOYL CHLORIDE(157373-08-5)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 23-26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 157373-08-5(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to pale yellow liquid

Uses

2,3,4-TRIFLUOROBENZOYL CHLORIDE is a reagent used in the preparation of Levofloxacin.

InChI:InChI=1/C7H2ClF3O/c8-7(12)3-1-2-4(9)6(11)5(3)10/h1-2H

Upstream product

• 61079-72-9 2,3,4,-trifluorobenzoic acid 
• 157766-29-5 2,3,4-trifluoro-benzotrichloride 

Downstream Products

• 100936-90-1 diethyl (2,3,4-trifluorobenzoyl)malonate 
• 915770-59-1 N-benzyl-2,3,4-trifluoro-N-(2-hydroxyethyl)benzamide 
• 915770-78-4 N-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)-2,3,4-trifluoro-N-methylbenzamide 
• 1597407-58-3 {3-hydroxy-3-[(S)-1-((S)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-azetidin-1-yl}-(2,3,4-trifluoro-phenyl)-methanone 
• 1401998-80-8 3-fluoro-2,4-dihydroxybenzaldehyde 
• 143879-80-5 2,3,4-trifluorobenzonitrile 
• 934660-93-2 [14C]-GDC-0973 
• 1369665-02-0 (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate 

Relevant articles and documents

Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening

As part of a search for a substrate for droplet-based microfluidic screening assay of α-N-acetylgalactosaminidases, spectral and physical characteristics of a series of coumarin derivatives were measured. From among these a new coumarin-based fluorophore, Jericho Blue, was selected as having optimal characteristics for our screen. A reliable method for the challenging synthesis of coumarin glycosides of α-GalNAc was then developed and demonstrated with nine examples. The α-GalNAc glycoside of Jericho Blue prepared in this way was shown to function well under screening conditions.

NOVEL PROCESS FOR MAKING COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.