1574312-57-4

Basic information

• Product Name: methyl 2-chloro-4-(3-nitrophenyl)pyrimidine-5-carboxylate
• CAS NO: 1574312-57-4
• Molecular Weight: 293.666
• Mol File: 1574312-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-chloro-4-(3-nitrophenyl)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloro-4-(3-nitrophenyl)pyrimidine-5-carboxylate(1574312-57-4)
• EPA Substance Registry System: methyl 2-chloro-4-(3-nitrophenyl)pyrimidine-5-carboxylate(1574312-57-4)

Safety Data

• Hazardous Substances Data: 1574312-57-4(Hazardous Substances Data)

Upstream product

• 1574312-49-4 methyl 4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 555-16-8 4-nitrobenzaldehdye 
• 1574312-53-0 methyl 4-(3-nitrophenyl)-2-oxo-1,2-dihydropyrimidine-5-carboxylate 

Downstream Products

• 1574312-43-8 2-(5-iodo-2-methylphenylamino)-4-(3-nitrophenyl)pyrimidine-5-carboxylic acid 
• 1574312-61-0 methyl 2-(5-iodo-2-methylphenylamino)-4-(3-nitrophenyl)pyrimidine-5-carboxylate 

Relevant articles and documents

Preparation of 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones and 2-(arylamino)pyrimidines

The Biginelli reaction of methyl propiolate and of methyl 3-diethylaminoacrylate has yielded a novel series of 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones. The successie oxidation of the pyrimidine ring, chlorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine give previously unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids have been obtained.