15789-03-4Relevant articles and documents
METHODS OF MAKING HIGH ENANTIOSELECTIVE SECONDARY ALCOHOLS
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Paragraph 0074; 0075, (2020/09/08)
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The "R-form" compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity, After then, the "S-form" compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.
Camptothecin derivative with antitumor activity, and preparation method and application thereof
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Paragraph 0105; 0107; 0111; 0113; 0118; 0120; 0124; 0126, (2019/11/04)
The present invention relates to a camptothecin derivative with antitumor activity, and a preparation method and an application thereof. The camptothecin derivative is a compound having a structure represented by general formula (I), or a pharmaceutically acceptable salt, an enantiomer, a diastereomer, a tautomer, a solvate, a polymorph or a prodrug thereof. The camptothecin derivative has a goodantitumor cell proliferation activity, has an inhibitory activity against specific tumor cells at a very low concentration, and has excellent selectivity; and the side effects of the camptothecin derivative represented by the general formula (I) are greatly less than those of Tripterygium wilfordii Hook. f., so the camptothecin derivative can be used to treat specific tumors.
(R)- AND (S)-1-(3-(3-N,N-DIMETHYLAMINOCARBONYL)PHENOXYL-4-NITROPHENYL)-1-ETHYL-N,N'-BIS (ETHYLENE)PHOSPHORAMIDATE, COMPOSITIONS AND METHODS FOR THEIR USE AND PREPARATION
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, (2017/06/12)
Provided herein are optically active compounds of the formulae (ii); and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of