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1586-03-4

1586-03-4

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Safety information and MSDS view more

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  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

SPIRO COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1 RECEPTOR

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Page/Page column 31, (2009/03/07)

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.

Research in the field of drugs with psychotropic activity. 11-piperazino 10,11-dihydro (a,d)dibenzo cycloheptene derivatives

Fouche,Blondel,Horclois,James,Leger,Poiget

, p. 3113 - 3130 (2007/10/05)

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Process route upstream and downstream products

Process route

2-benzylbenzyl bromide
55276-42-1

2-benzylbenzyl bromide

potassium cyanide
151-50-8

potassium cyanide

2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
In ethanol;
In ethanol; for 8h; Heating / reflux;
2-(benzyl)benzyl alcohol
1586-00-1

2-(benzyl)benzyl alcohol

2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: aq. HBr
2: ethanol
With hydrogen bromide; In ethanol;
Multi-step reaction with 2 steps
1: aqueous HBr
With hydrogen bromide;
Multi-step reaction with 2 steps
1: aqueous HBr
With hydrogen bromide;
Multi-step reaction with 2 steps
1: aq. HBr
With hydrogen bromide;
2-benzyl-benzoic acid methyl ester
6962-60-3

2-benzyl-benzoic acid methyl ester

2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: LiAlH4 / diethyl ether
2: aq. HBr
3: ethanol
With lithium aluminium tetrahydride; hydrogen bromide; In diethyl ether; ethanol;
Multi-step reaction with 3 steps
1: LiAlH4; diethyl ether
2: aqueous HBr
With lithium aluminium tetrahydride; diethyl ether; hydrogen bromide;
Multi-step reaction with 3 steps
1: LiAlH4; diethyl ether
2: aqueous HBr
With lithium aluminium tetrahydride; diethyl ether; hydrogen bromide;
Multi-step reaction with 3 steps
1: LiBH4
2: aq. HBr
With lithium borohydride; hydrogen bromide;
2-Benzoylbenzoic acid
85-52-9

2-Benzoylbenzoic acid

2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: Zn; aq. NaOH / Heating
2: diethyl ether
3: LiAlH4 / diethyl ether
4: aq. HBr
5: ethanol
With sodium hydroxide; lithium aluminium tetrahydride; hydrogen bromide; zinc; In diethyl ether; ethanol;
Multi-step reaction with 5 steps
1: H2 / Pd-C
2: H2SO4
3: LiBH4
4: aq. HBr
With lithium borohydride; sulfuric acid; hydrogen bromide; hydrogen; palladium on activated charcoal;
2-benzylbenzyl bromide
55276-42-1

2-benzylbenzyl bromide

sodium cyanide
143-33-9,25596-52-5

sodium cyanide

2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

Conditions
Conditions Yield
entsprech. Chlorid, NaCN;
2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

2-(2-benzylphenyl)acetic acid
36374-49-9

2-(2-benzylphenyl)acetic acid

Conditions
Conditions Yield
With sulfuric acid; acetic acid;
With potassium hydroxide;
With sulfuric acid; acetic acid; Heating;
With potassium hydroxide; water; In ethanol; for 20h; Heating / reflux;
2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

mechlorethamine hydrochloride
55-86-7

mechlorethamine hydrochloride

1-methyl-4-[2-(phenylmethyl)phenyl]-4-piperidinecarbonitrile
1111728-10-9

1-methyl-4-[2-(phenylmethyl)phenyl]-4-piperidinecarbonitrile

Conditions
Conditions Yield
With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 2h;
2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

methyl iodide
74-88-4

methyl iodide

2-(2-benzylphenyl)-2-methylpropanenitrile

2-(2-benzylphenyl)-2-methylpropanenitrile

Conditions
Conditions Yield
2-(2-benzylphenyl)acetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; Inert atmosphere;
methyl iodide; In tetrahydrofuran; mineral oil; Inert atmosphere; Reflux;
71%
2-(2-benzylphenyl)acetonitrile
1586-03-4

2-(2-benzylphenyl)acetonitrile

(2-benzyl-phenyl)-acetic acid amide
62551-12-6

(2-benzyl-phenyl)-acetic acid amide

Conditions
Conditions Yield

Global suppliers and manufacturers

Global( 2) Suppliers
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  • Emails
  • Main Products
  • Country
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:33
  • Country:China (Mainland)
  • PRIME MOLECULAR CO.,LIMITED
  • Business Type:Trading Company
  • Contact Tel:0852-0755-61104662
  • Emails:sales@prime-molecular.com
  • Main Products:1
  • Country:China (Mainland)
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