1595275-29-8Relevant articles and documents
METHODS OF SYNTHESIS AND INTERMEDIATES
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Page/Page column 18; 20, (2020/09/12)
A method of synthesising a compound of formula (I) from a compound of formula (II) wherein R2 is phenyl, substituted at either the meta- or para-position by the group (III) where Q is an amino acid residue (-C(=O)-X1-NH-), a di-amino acid residue (-C(=O)-X1-X2-NH-) or a tri-amino acid residue (-C(=O)-X1-X2-X3-NH-); ProtN3 is an amino protecting group; R2pre is phenyl, substituted at the same position as R2 by -NH2; comprising reacting a compound of formula (II) with a compound of formula (IV) in the presence of HATU in dichloromethane or chloroform or a mixture thereof.
NOVEL ANTIBODY CONJUGATES AND USES THEREOF
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Page/Page column 129; 132, (2014/09/03)
Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.
SYNTHESIS AND INTERMEDIATES OF PYRROLOBENZODIAZEPINE DERIVATIVES FOR CONJUGATION
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Page/Page column 49, (2014/05/07)
A method of synthesing a compound of formula (I) from a compound of formula (III).