1596-67-4

Basic information

• Product Name: L-THYRONINE
• Synonyms: S-THYRONINE;O-4-HYDROXYPHENYL-L-TYROSINE;TYROSINE(4-HYDROXYPHENYL)-OH;ALPHA-AMINO-BETA-(4-HYDROXYPHENOXYPHENYL) PROPIONIC ACID;3-[P-(P-HYDROXYPHENOXY)PHENYL]-L-ALANINE;L-THYRONINE;H-BETA-[4-(4-HYDROXYPHENOXY)-PHENYL]-ALA-OH;H-4-(4-HYDROXYPHENOXY)-PHE-OH
• CAS NO: 1596-67-4
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.28
• EINECS: 216-483-8
• Product Categories: Amino Acids
• Mol File: 1596-67-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 259-260℃
• Boiling Point: 477.694 °C at 760 mmHg
• Flash Point: 242.701 °C
• Appearance: /
• Density: 1.324 g/cm³
• Storage Temp.: -15°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: L-THYRONINE(CAS DataBase Reference)
• NIST Chemistry Reference: L-THYRONINE(1596-67-4)
• EPA Substance Registry System: L-THYRONINE(1596-67-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 1596-67-4(Hazardous Substances Data)

Usage

Chemical Properties

Slightly yellow powder

Uses

L-Thyronine is a type of thyroid hormone. Thyroid hormones are important regulators of growth and maturation before birth in mammals.

InChI:InChI=1/C15H15NO4/c16-14(15(18)19)9-10-1-5-12(6-2-10)20-13-7-3-11(17)4-8-13/h1-8,14,17H,9,16H2,(H,18,19)

Upstream product

• 51-48-9 L-thyroxine 
• 1041-01-6 3,5-diiodo-L-thyronine 
• 904809-09-2 O-(4-amino-phenyl)-N-benzoyl-L-tyrosine 
• 3483-82-7 N-benzoyl-L-tyrosine ethyl ester 
• 53663-23-3 1,2,3-triiodo-5-nitrobenzene 
• 949-67-7 L-tyrosine ethyl ester 
• 908571-78-8 O-(2.6-diiodo-4-amino-phenyl)-N-benzoyl-L-tyrosine 
• 904809-03-6 O-(2.6-diiodo-4-nitro-phenyl)-N-benzoyl-L-tyrosine 
• 904808-96-4 O-(2.6-diiodo-4-nitro-phenyl)-N-benzoyl-L-tyrosine ethyl ester 
• 1034-10-2 DL-thyronine 
• 6893-02-3 triiodothyronine 
• 5817-39-0 L-3,3',5'-triiodothyronine 
• 70-40-6 L-3,3'-Diiodothyronine 

Relevant articles and documents

Remarkable Effect of Chalcogen Substitution on an Enzyme Mimetic for Deiodination of Thyroid Hormones

Iodothyronine deiodinases are selenoenzymes which regulate the thyroid hormone homeostasis by catalyzing the regioselective deiodination of thyroxine (T4). Synthetic deiodinase mimetics are important not only to understand the mechanism of enzyme catalysis, but also to develop therapeutic agents as abnormal thyroid hormone levels have implications in different diseases, such as hypoxia, myocardial infarction, critical illness, neuronal ischemia, tissue injury, and cancer. Described herein is that the replacement of sulfur/selenium atoms in a series of deiodinase mimetics by tellurium remarkably alters the reactivity as well as regioselectivity toward T4. The tellurium compounds reported in this paper represent the first examples of deiodinase mimetics which mediate sequential deiodination of T4 to produce all the hormone derivatives including T0 under physiologically relevant conditions.