1597407-55-0

Basic information

• Product Name: Cobimetinib intermediate2
• Synonyms: Cobimetinib intermediate2;tert-butyl 3-((3S,5R,8aS)-5-cyano-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridin-5-yl)-3-hydroxyazetidine-1-carboxylate
• CAS NO: 1597407-55-0
• Molecular Formula: C₂₂H₂₉N₃O₄
• Molecular Weight: 399.48
• EINECS: -0
• Mol File: 1597407-55-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 560.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 11.98±0.20(Predicted)
• CAS DataBase Reference: Cobimetinib intermediate2(CAS DataBase Reference)
• NIST Chemistry Reference: Cobimetinib intermediate2(1597407-55-0)
• EPA Substance Registry System: Cobimetinib intermediate2(1597407-55-0)

Safety Data

• Hazardous Substances Data: 1597407-55-0(Hazardous Substances Data)

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 106565-71-3 (3S,5R,8aS)-3-phenylhexahydro-2H-oxazolo[3,2-a]pyridine-5-carbonitrile 

Downstream Products

• 1369665-02-0 (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemifumarate 
• 934660-93-2 [14C]-GDC-0973 
• 1597407-58-3 {3-hydroxy-3-[(S)-1-((S)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-azetidin-1-yl}-(2,3,4-trifluoro-phenyl)-methanone 
• 1597407-56-1 3-hydroxy-3-[(S)-1-((S)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]azetidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE

This disclosure relates to the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-l-yl]-methanone. The disclosure also relates to pharmaceutical compositions comprising the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-l-yl]-methanone. The disclosure also relates to methods of treating cancers comprising administering to a patient in need thereof the crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone.