159857-60-0

Basic information

• Product Name: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine
• Synonyms: (S)-2-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonylamino)-6-((4-methoxyphenyl)diphenylmethylamino)hexanoic acid;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[(4-methoxyphenyl)diphenylmethyl]-L-lysine;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexan;N6-(4-Methoxytrityl)-L-lysine, N2-FMOC protected;N6-[Diphenyl(4-methoxyphenyl)methyl]-N2-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-lysine, FMOC-L-LYS(MMT)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)hexanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(((4-Methoxyphenyl)diphenylmethyl)amino)he;Nα-Fmoc-Nε-4-methoxyyltrityl-L-lysine≥ 99.8% (HPLC, Chiral purity)
• CAS NO: 159857-60-0
• Molecular Formula: C₄₁H₄₀N₂O₅
• Molecular Weight: 640.7667
• Product Categories: amino acids
• Mol File: 159857-60-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 814.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.210
• Storage Temp.: Store at +2°C to +8°C.
• PKA: 3.83±0.21(Predicted)
• CAS DataBase Reference: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(159857-60-0)
• EPA Substance Registry System: N-alpha-Fmoc-N-epsilon-4-methoxytrityl-L-lysine(159857-60-0)

Safety Data

• Hazardous Substances Data: 159857-60-0(Hazardous Substances Data)

Usage

Chemical Properties

White to pale brown solid

General Description

An excellent derivative for the synthesis of branched peptides and peptides modified at the lysine side-chain [1], and for the construction of templates and multifunctionalized resins for combinatorial synthesis.The side-chain Mmt group can be selectively removed in the same manner as Mtt with 1% TFA in DCM [2, 3, 4] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) [5]. Alternatively, it can be removed under milder conditions with AcOH/TFE/DCM (1:2:7) [1], leaving Mtt intact.The product number for this product was previously 04-12-1232.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Upstream product

• 105047-45-8 Fmoc-Lys-OH 
• 14470-28-1 mono-4-methoxytrityl chloride 

Downstream Products

• 159857-61-1 (S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid 
• 439286-56-3 (S)-2-Amino-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide 

Relevant articles and documents

Cobalamin conjugates for anti-tumor therapy

The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently