Welcome to LookChem.com Sign In|Join Free

Cas Database

1603837-67-7

1603837-67-7

Identification

  • Product Name:6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

  • CAS Number: 1603837-67-7

  • EINECS:

  • Molecular Weight:334.42

  • Molecular Formula: C24H18N2

  • HS Code:

  • Mol File:1603837-67-7.mol

Synonyms:6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase

Relevant articles and documentsAll total 1 Articles be found

Arylative cyclization of 2-isocyanobiphenyls with anilines: One-pot synthesis of 6-arylphenanthridines via competitive reaction pathways

Xia, Zhonghua,Huang, Jinbo,He, Yimiao,Zhao, Jiaji,Lei, Jian,Zhu, Qiang

, p. 2546 - 2549 (2014/05/20)

A transition-metal-free method for the synthesis of C6 phenanthridine derivatives by arylative cyclization of 2-isocyanobiphenyls with arylamines in one pot was developed. Mechanistic studies suggest that electrophilic aromatic substitution (SEAr) of a nitrilium intermediate and homolytic aromatic substitution (HAS) of an imidoyl radical intermediate are two competitive reaction pathways involved in the annulation step.

Process route upstream and downstream products

Process route

2-(1H-pyrrol-1-yl)aniline
6025-60-1

2-(1H-pyrrol-1-yl)aniline

2-isocyano-5-methyl-1,1'-biphenyl
1428264-89-4

2-isocyano-5-methyl-1,1'-biphenyl

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
With tert.-butylnitrite; sodium acetate; N,N`-dimethylethylenediamine; dibenzoyl peroxide; at 20 - 70 ℃; for 3.08333h; Schlenk technique; Inert atmosphere;
72%
2-bromo-p-toluidine
583-68-6

2-bromo-p-toluidine

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere
1.2: 20 - 80 °C / Inert atmosphere
2.1: tetrahydrofuran / 2 h / 0 - 20 °C
3.1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water;
phenylboronic acid
98-80-6

phenylboronic acid

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere
1.2: 20 - 80 °C / Inert atmosphere
2.1: tetrahydrofuran / 2 h / 0 - 20 °C
3.1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water;
C<sub>14</sub>H<sub>13</sub>NO
1428264-96-3

C14H13NO

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran;
2-amino-5-methylbiphenyl
42308-28-1

2-amino-5-methylbiphenyl

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 2 h / 0 - 20 °C
2: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran;
2-(1H-pyrrol-1-yl)aniline
6025-60-1

2-(1H-pyrrol-1-yl)aniline

2-isocyano-5-methyl-1,1'-biphenyl
1428264-89-4

2-isocyano-5-methyl-1,1'-biphenyl

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
With tert.-butylnitrite; sodium acetate; N,N`-dimethylethylenediamine; dibenzoyl peroxide; at 20 - 70 ℃; for 3.08333h; Schlenk technique; Inert atmosphere;
72%
2-bromo-p-toluidine
583-68-6

2-bromo-p-toluidine

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere
1.2: 20 - 80 °C / Inert atmosphere
2.1: tetrahydrofuran / 2 h / 0 - 20 °C
3.1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water;
phenylboronic acid
98-80-6

phenylboronic acid

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere
1.2: 20 - 80 °C / Inert atmosphere
2.1: tetrahydrofuran / 2 h / 0 - 20 °C
3.1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
4.1: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; potassium carbonate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water;
C<sub>14</sub>H<sub>13</sub>NO
1428264-96-3

C14H13NO

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
2: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran;
2-amino-5-methylbiphenyl
42308-28-1

2-amino-5-methylbiphenyl

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine
1603837-67-7

6-(2-(1H-pyrrol-1-yl)phenyl)-2-methylphenanthridine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 2 h / 0 - 20 °C
2: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
3: dibenzoyl peroxide; sodium acetate; N,N`-dimethylethylenediamine; tert.-butylnitrite / 3.08 h / 20 - 70 °C / Schlenk technique; Inert atmosphere
With tert.-butylnitrite; sodium acetate; triethylamine; N,N`-dimethylethylenediamine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran;

Global suppliers and manufacturers

Global( 0) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1603837-67-7
Post Buying Request Now
close
Remarks: The blank with*must be completed