160705-94-2

Basic information

• Product Name: 2R-t-butyldiphenylsilyloxymethyl-4S-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane
• CAS NO: 160705-94-2
• Molecular Weight: 509.701
• Mol File: 160705-94-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2R-t-butyldiphenylsilyloxymethyl-4S-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2R-t-butyldiphenylsilyloxymethyl-4S-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(160705-94-2)
• EPA Substance Registry System: 2R-t-butyldiphenylsilyloxymethyl-4S-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(160705-94-2)

Safety Data

• Hazardous Substances Data: 160705-94-2(Hazardous Substances Data)

Upstream product

• 133120-44-2 N-(2-Oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-acetamide 
• 186707-06-2 Trans and Cis-2R-t-butyldiphenylsilyloxymethyl-4-acetoxy-1,3-oxathiolane 
• 160579-76-0 tert-Butyl-((R)-3-oxo-3λ⁴-[1,3]oxathiolan-2-ylmethoxy)-diphenyl-silane 
• 160579-75-9 2R-t-butyldiphenylsilyloxymethyl-1,3-oxathiolane 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 160707-69-7 (1'S,4'R)-deoxy-3'-oxathiocytidine 

Relevant articles and documents

Substituted 1,3-oxathiolanes with antiviral properties

This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1is hydrogen, and R2is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.

Anti-Human Immunodeficiency Virus and Anti-Hepatitis-B Virus Activities and Toxicities of the Enantiomers of 2'-Deoxy-3'-oxa-4'-thiocytidine and Their 5-Fluoro Analogues in Vitro

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