1617-17-0 Usage
Description
2-Chloropropionitrile (2-CPN) is a colorless flammable liquid
with a characteristic acrid odor.
Uses
Different sources of media describe the Uses of 1617-17-0 differently. You can refer to the following data:
1. Major uses of this chemical are in pharmaceutics and polymer
synthesis.
2. 2-Chloropropionitrile was used as initiator during the single-pot atom-transfer radical polymerization under microwave irradiation for the synthesis of polyacrylonitrile. It was used in the synthesis of:nitrile functionalized methimazole-based ionic liquids(+)- and (-)-anatoxin
Environmental Fate
Most of the toxicity of propionitrile results from release of
cyanide. Cause of death is due to lack of oxygen to the body’s
cells, especially to the brain and heart cells.
Acquired resistance
According to Henry’s law constant of 1.43×10-5 atmm3
mol-1, vapor pressure of 2.770mmHg and water solubility
of 45 g ml-1 at 25°C are expected to indicate that
volatilization from moist soil and water surfaces is expected
to be an important fate process and also it can be volatilized
from dry soil surfaces and exist as a vapor in the
atmosphere.When heated to decomposition, it emits very toxic fumes of
chlorine-containing compounds: nitrogen oxides, hydrogen
cyanide, and hydrogen chloride.
Check Digit Verification of cas no
The CAS Registry Mumber 1617-17-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,1 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1617-17:
(6*1)+(5*6)+(4*1)+(3*7)+(2*1)+(1*7)=70
70 % 10 = 0
So 1617-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H4ClN/c1-3(4)2-5/h3H,1H3
1617-17-0Relevant articles and documents
-
Davies,Maclaren
, p. 2595,2597 (1951)
-
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles
Kadunce, Nathaniel T.,Reisman, Sarah E.
supporting information, p. 10480 - 10483 (2015/09/28)
A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks. The reaction tolerates a variety of heterocyclic coupling partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines. The reaction proceeds under mild conditions at room temperature and precludes the need to pregenerate organometallic nucleophiles.
Reinvestigation of the reaction of trichloroacetyl chloride and acrylonitrile in the preparation of 3,5,6-trichloropyridin-2-ol
Fakhraian,Moghimi,Bazaz,Hadj-Ghanbary,Sadeghi
, p. 329 - 333 (2013/09/06)
The synthesis of 3,5,6-trichloropyridin-2-ol via the CuCl-catalyzed reaction of trichloroacetyl chloride and acrylonitrile under both pressure and atmospheric conditions and the hydrolysis of the reaction mixture were reinvestigated. The products and byproducts formed in each case, before the hydrolysis step, were characterized, and the factors causing their formation are discussed. It was found that two newly identified byproducts influence the yield of the reaction.
