1620568-16-2

Basic information

• Product Name: C₂₄H₂₇N₃O₆
• Synonyms: C₂₄H₂₇N₃O₆
• CAS NO: 1620568-16-2
• Molecular Weight: 453.495
• Mol File: 1620568-16-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₇N₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₇N₃O₆(1620568-16-2)
• EPA Substance Registry System: C₂₄H₂₇N₃O₆(1620568-16-2)

Safety Data

• Hazardous Substances Data: 1620568-16-2(Hazardous Substances Data)

Upstream product

• 178972-26-4 tert-butyl 4-isocyanatobenzylcarbamate 
• 72776-05-7 (S)-benzyl 4-oxoazetidine-2-carboxylate 
• 2791-79-9 dibenzyl L-aspartate 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 

Downstream Products

• 1620568-08-2 (S)-(2-carboxy-4-oxoazetidine-1-carboxamido)phenylmethanaminium 2,2,2-trifluoroacetate 

Relevant articles and documents

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

The αvβ3 and α5β 1 integrins are widely expressed in different cancer types and recognize the tripeptide Arg-Gly-Asp (RGD) motif present in several extracellular matrix proteins. We report here the design, synthesis and biological activity of some new β-lactam derivatives specifically designed to target integrins. The new molecules contain the azetidinone as the only cyclic framework armed with carboxylic acid and amine terminals spaced from 9 to 14 atoms to switch on recognition by integrins. All tested molecules showed a concentration-dependent enhancement in fibronectin-mediated adhesion of K562 and SK-MEL-24 cells; in particular 1, expressed a higher affinity towards α5β1 integrin (EC50 of 12 nM) and 2 was more selective for integrin αvβ3 (EC 50 of 11 nM).