162247-66-7

Basic information

• Product Name: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-5-oxo-4-phenyl-, ethyl ester
• Synonyms: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-5-oxo-4-phenyl-, ethyl ester
• CAS NO: 162247-66-7
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.24662
• Mol File: 162247-66-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 341.6±52.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 0.95±0.40(Predicted)
• CAS DataBase Reference: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-5-oxo-4-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-5-oxo-4-phenyl-, ethyl ester(162247-66-7)
• EPA Substance Registry System: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-methyl-5-oxo-4-phenyl-, ethyl ester(162247-66-7)

Safety Data

• Hazardous Substances Data: 162247-66-7(Hazardous Substances Data)

Upstream product

• 54681-67-3 2-acetamido-3-ethoxy-3-oxopropanoic acid 
• 3076-54-8 phenyllead(IV) triacetate 
• 162247-62-3 4-Ethoxycarbonyl-2-methyl-4,5-dihydro-1,3-oxazol-5-one 

Downstream Products

• 14257-84-2 (S)-N-acetyl-2-phenylglycine 
• 2935-35-5 (S)-2-phenylglycine 
• 14190-09-1 N-acetyl-α-(D)-phenylglycine ethyl ester 
• 14257-84-2 (R)-(-)-N-acetylphenylglycine 
• 14257-84-2 N-acetyl-α-phenylglycine 

Relevant articles and documents

Reaction of organolead triacetates with 4-ethoxycarbonyl-2-methyl-4,5-dihydro-1,3-oxazol-5-one. The synthesis of α-aryl- and α-vinyl-N-acetylglycines and their ethyl esters and their enzymic resolution

4-Ethoxycarbonyl-2-methyl-4,5-dihydro-1,3-oxazol-5-one 7, which may be readily obtained from diethyl acetamidomalonate, undergoes high-yielding arylation and vinylation at the 4-position with organolead triacetates to give compounds which may be hydrolysed to give either the α-aryl- or α-vinyl-N-acetylglycine or the corresponding ethyl ester. The kinetic resolution of a number of these derivatives by enzymic hydrolysis of either the amide or ester function has been demonstrated.