162271-15-0

Basic information

• Product Name: 4-broMo-3-(1,3-dioxolan-2-yl)phenol
• Synonyms: 4-broMo-3-(1,3-dioxolan-2-yl)phenol;2-bromo-4-(1,3-dioxolan-2-yl)phenol
• CAS NO: 162271-15-0
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.06996
• Mol File: 162271-15-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-broMo-3-(1,3-dioxolan-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-3-(1,3-dioxolan-2-yl)phenol(162271-15-0)
• EPA Substance Registry System: 4-broMo-3-(1,3-dioxolan-2-yl)phenol(162271-15-0)

Safety Data

• Hazardous Substances Data: 162271-15-0(Hazardous Substances Data)

Upstream product

• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 162271-46-7 2-[3-bromo-4-(methoxymethoxy)phenyl]-1,3-dioxolane 
• 223418-72-2 2-(3-bromo-4-methoxyphenyl)-1,3-dioxolane 
• 1026243-11-7 C₁₄H₁₇BrO₄ 
• 1027658-03-2 C₁₅H₂₃BrO₃Si 
• 1601390-46-8 (E)-1-(5-(1,3-dioxolan-2-yl)-2-hydroxyphenyl)-3,7-dimethylocta-2,6-dien-1-one 
• 1601390-47-9 (E)-3-(3,7-dimethylocta-2,6-dienoyl)-4-hydroxybenzaldehyde 
• 1601390-03-7 (R)-3-(3,7-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oct-6-enoyl)-4-hydroxybenzoic acid 
• 1601390-01-5 (R)-3-(3,7-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oct-6-enoyl)-4-hydroxybenzaldehyde 
• 1178514-11-8 (2E,6E,10E)-4-benzyloxy-3-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)benzoic acid benzyl ester 
• 690256-47-4 (2E,6E,10E)-4-acetoxy-3-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)benzoic acid 
• 39703-10-1 (2E,6E,10E)-4-hydroxy-3-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)benzoic acid 
• 104777-73-3 4-hydroxy-3-<1'-(2'E,6'E)-3',7',11'-trimethyl-2',6',10'-dodecatrienyl>benzoic acid 
• 1178514-10-7 (2E,6E,10E)-4-hydroxy-3-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)benzaldehyde 
• 1178514-09-4 (2E,6E)-4-hydroxy-3-(3,7,11-trimethyldodeca-2,6,10-trienyl)benzaldehyde 

Relevant articles and documents

Direct Syn Addition of Two Silicon Atoms to a C≡C Triple Bond by Si?Si Bond Activation: Access to Reactive Disilylated Olefins

A catalytic intramolecular silapalladation of alkynes affords, in good yields and stereoselectively, syn-disilylated heterocycles of different chemical structure and size. When applied to silylethers, this reaction leads to vinylic silanols that undergo a rhodium-catalyzed addition to activated olefins, providing the oxa-Heck or oxa-Michael products, depending on the reaction conditions.

Bioactive prenylated phenyl derivatives derived from marine natural products: Novel scaffolds for the design of BACE inhibitors

Abnormal accumulation of neurotoxic beta-amyloid peptides (Aβ) is a key factor in the development of Alzheimer's disease (AD) and strategies to reduce Aβ production constitute an active field of research for the development of novel therapeutic agents for the treatment of AD. In particular, β-secretase-1 (BACE-1) has been a prime target for modulating Aβ production although obtaining drug-like BACE-1 inhibitors has proven to be highly challenging. Here we report the isolation and biochemical characterization of a marine natural product, the prenylated hydroxybenzoic acid 1, with BACE-1 inhibitory activity and ability to decrease Aβ production in cell-based assays. Synthesis and biological activity of a number of new synthetic analogues are also reported, as well as initial structure-activity relationship (SAR) analysis on this chemical family. Hence, these compounds constitute novel scaffolds from which more potent and selective BACE-1 inhibitors could be designed as potential therapeutic agents for the treatment of Alzheimer's disease.

CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF

Substituted flavonoid compounds, and pharmaceutical formulations of flavonoid compounds are described. Also described are processes for preparing flavonid compounds, as are methods for treating cancer in mammals using the described flavonoid compounds or pharmaceutical formulations thereof.