1623-24-1

Basic information

• Product Name: isopropyl dihydrogen phosphate
• Synonyms: isopropyl dihydrogen phosphate;Phosphoric acid, mono(1-methylethyl) ester;MONOISOPROPYLPHOSPHATE;Phosphoric acid dihydrogen isopropyl ester;Dihydrogen isopropyl phosphate;Isopropyl acid phosphate solid;Isopropyl alcohol, monophosphated;Isopropyl hydrogen phosphate
• CAS NO: 1623-24-1
• Molecular Formula: C₃H₉O₄P
• Molecular Weight: 140.074921
• EINECS: 216-607-0
• Mol File: 1623-24-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 250.5°Cat760mmHg
• Flash Point: 105.3°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 0.00682mmHg at 25°C
• Refractive Index: 1.443
• CAS DataBase Reference: isopropyl dihydrogen phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl dihydrogen phosphate(1623-24-1)
• EPA Substance Registry System: isopropyl dihydrogen phosphate(1623-24-1)

Safety Data

• Hazardous Substances Data: 1623-24-1(Hazardous Substances Data)

Usage

General Description

isopropyl dihydrogen phosphate is a white crystalline solid. isopropyl dihydrogen phosphate is corrosive to metals and tissue.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

A highly corrosive material. Very irritating to the skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of POx. See also ESTERS

InChI:InChI=1/C3H9O4P/c1-3(2)7-8(4,5)6/h3H,1-2H3,(H2,4,5,6)

Upstream product

• 75-30-9 2-iodo-propane 
• 187737-37-7 propene 
• 60763-39-5 isopropyl diphenyl phosphate 
• 67-63-0 isopropyl alcohol 
• 3424-21-3 triisopropylamine 
• 39683-66-4 2-isopropyloxy-2-oxo-1,3,2-dioxaphospholane 
• 58544-31-3 phosphoric acid isopropyl ester bis-(4-methoxy-phenyl) ester 
• 10428-95-2 O,O-diisopropyl-S-(2-butenyl) thiophosphate 
• 60-29-7 diethyl ether 
• 86119-84-8 phosphoric acid 
• 1992-48-9 Tetraisopropoxysilan 
• 867-17-4 diethyl methyl phosphate 
• 10463-05-5 dimethyl ethylphosphonate 
• 56376-11-5 isopropyl phosphorodichloridate 

Downstream Products

• 3019-20-3 isopropylthiobenzene 

Relevant articles and documents

METHOD FOR PRODUCING PHOSPHOESTER COMPOUND

PROBLEM TO BE SOLVED: To provide a method whereby, a phosphate compound selected from the group consisting of orthophosphoric acid, phosphonic acid, phosphinic acid, and anhydrides of them is used as raw material and, by one stage reaction, a corresponding phosphoester compound is produced. SOLUTION: To an aqueous solution of a phosphate compound, added is an organic silane or siloxane compound having an alkoxy group or an aryloxy group, and the mixture is subjected to a heating reaction, thereby producing a corresponding phosphoester compound without requiring a catalyst. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Regioselective phosphorylation of carbohydrates and various alcohols by bacterial acid phosphatases; probing the substrate specificity of the enzyme from Shigella flexneri

Bacterial non-specific acid phosphatases normally catalyze the dephosphorylation of a variety of substrates. As shown previously the enzymes from Shigella flexneri and Salmonella enterica are also able to catalyze the phosphorylation of inosine to inosine monophosphate and D-glucose to D-glucose 6-phosphate (D-G6P) using cheap pyrophosphate as the phosphate donor. After optimization high yields (95%) are achieved in the latter reaction and we show here that it is possible to use these enzymes in a preparative manner. This prompted us to investigate by using 31P NMR and HPLC also the phosphorylation of a broad range of carbohydrates and alcohols. Many cyclic carbohydrates are phosphorylated in a regioselective manner. Non-cyclic carbohydrates are phosphorylated as well. Phosphorylation of linear alcohols, cyclic and aromatic alcohols is also possible. In all cases the acid phosphatase from Shigella prefers a primary alcohol function above a secondary one. We conclude that these enzymes are an attractive alternative to existing chemical and enzymatic methods in the phosphorylation of a broad range of compounds.

Poly-perfluoroalkyl-substituted alcohols and acids, and derivatives thereof

Di-, tri- and poly-perfluoroalkyl-substituted alcohols and acids and derivatives thereof are described which are prepared from perfluoroalkyl iodides and di-, tri- or polyallyl alcohols or acids. These compounds contain two or more perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkenyl groups and one or two alcohol or acid groups or derivatized alcohol or acid functions. They can be reacted with isocyanates, epoxy compounds, anhydrides, acids or acid derivatives to prepare a great variety of oil- and water-repellent compositions which are useful for oil- and water-repellent treatment of textiles, glass, paper, leather and other substrates.