16252-53-2

Basic information

• Product Name: (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 16252-53-2
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.2219
• Mol File: 16252-53-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 383.4°C at 760 mmHg
• Flash Point: 152.1°C
• Density: 1.317g/cm³
• Vapor Pressure: 1.46E-06mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(16252-53-2)
• EPA Substance Registry System: (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one(16252-53-2)

Safety Data

• Hazardous Substances Data: 16252-53-2(Hazardous Substances Data)

Usage

General Description

(2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one is a chemical compound that belongs to the family of naphthalenones. It is a yellow solid compound with a molecular formula C12H12O3 and a molecular weight of 204.22 g/mol. (2E)-2-(hydroxymethylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one is known for its potential biological activities and is currently being researched for its pharmacological properties. It has been identified as a potential anti-inflammatory and antioxidant agent, and has shown promising results in various studies. Additionally, it has been evaluated for its potential application in the development of new drugs for the treatment of various diseases.

Upstream product

• 109-94-4 formic acid ethyl ester 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 

Downstream Products

• 74039-98-8 2-cyano-6-methoxy-2-methyl-1-tetralone 
• 518360-20-8 2-(7-Methoxy-4,5-dihydrobenzo[g]indazol-1-yl)-1-methylethylamine 
• 57595-75-2 7-methoxy-2-phenyl-4,5-dihydro-2H-benzo[g]indazole 
• 52927-22-7 6-cyano-2-naphthol 
• 67886-70-8 2-cyano-6-methoxynaphthalene 
• 2472-02-8 (±)-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde 
• 1402041-09-1 3-(2,5-dimethoxybenzyl)-6-methoxy-2-methylnaphthalene-1,4-dione 
• 1402041-10-4 3-(3,5-dimethoxybenzyl)-6-methoxy-2-methylnaphthalene-1,4-dione 
• 1402041-08-0 6-methoxy-2-methyl-3-(4-trifluoromethylbenzyl)naphthalene-1,4-dione 
• 1402041-07-9 3-(4-bromobenzyl)-6-methoxy-2-methylnaphthalene-1,4-dione 
• 27752-24-5 6-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one 
• 117661-44-6 7-methoxy-2-nitro-naphto<1,2-b>furan 
• 119047-56-2 1ζ-acetoxy-6-methoxy-2-(p-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydronaphthalene 
• 52924-01-3 6-methoxy-1-(p-methoxyphenyl)-2-methyl-3,4-dihydronaphthalene 

Relevant articles and documents

Probing Intramolecular Electron Transfer in Redox Tag Processes

Herein, we show that redox tag-guided intermolecular formal [2 + 2] cycloaddition can be used as a probe to investigate intramolecular single-electron transfer (SET) mechanisms. The efficacy of intramolecular SET can be evaluated in association with concomitant carbon-carbon bond formation and/or cleavage, leading to cycloaddition or cross-metathesis. Experimental and theoretical results suggest that the intramolecular SET is under both thermodynamic and kinetic control and can also occur through bonds, not only through space.

Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents

Catechol diethers that incorporate a 7-cyano-2-naphthyl substituent are reported as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Many of the compounds have 1-10 nM potencies toward wild-type HIV-1. An interesting conformational effect allows two unique conformers for the naphthyl group in complexes with HIV-RT. X-ray crystal structures for 4a and 4f illustrate the alternatives.

TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS

Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and their use as antimalarial or antischistosomal agents.