16339-21-2

Basic information

• Product Name: 4-Methyl-4-(methylnitrosoamino)-2-pentanone
• Synonyms: 4-Methyl-4-(methylnitrosoamino)-2-pentanone;2-Methylnitrosamino-2-methylpentanon(4);2-Methylnitrosamino-2-methylpentanon(4) [german];2-Pentanone, 4-methyl-4-(N-nitrosomethylamino)-;4-Methyl-4-(N-nitrosomethylamino)-2-pentanone;Brn 1765427;Methyl-1,1-dimethylbutanon(3)-nitrosamin;Methyl-1,1-dimethylbutanon(3)-nitrosamin [german]
• CAS NO: 16339-21-2
• Molecular Formula: C7H14 N2 O2
• Molecular Weight: 158.23
• Mol File: 16339-21-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 283.28°C (rough estimate)
• Flash Point: 120.9°C
• Appearance: /
• Density: 1.1414 (rough estimate)
• Vapor Pressure: 0.00485mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• PKA: -3.87±0.70(Predicted)
• CAS DataBase Reference: 4-Methyl-4-(methylnitrosoamino)-2-pentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-4-(methylnitrosoamino)-2-pentanone(16339-21-2)
• EPA Substance Registry System: 4-Methyl-4-(methylnitrosoamino)-2-pentanone(16339-21-2)

Safety Data

• Hazardous Substances Data: 16339-21-2(Hazardous Substances Data)

Usage

General Description

4-Methyl-4-(methylnitrosoamino)-2-pentanone is a chemical compound known for its potential mutagenic and carcinogenic properties. It is commonly used in research and testing as a model compound for studying the effects of nitrosamines, which are environmental toxins and potent carcinogens. The compound has been found to induce DNA damage and mutations in various in vitro and in vivo studies. Due to its potential health risks, efforts are being made to understand its mechanisms of action and develop strategies for minimizing exposure to this hazardous compound.

InChI:InChI=1/C7H14N2O2/c1-6(10)5-7(2,3)9(4)8-11/h5H2,1-4H3

Upstream product

• 52221-51-9 4-methyl-4-(methylamino)pentan-2-one 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 74-89-5 methylamine 

Downstream Products

• 186581-53-3 diazomethane 
• 141-79-7 4-methyl-pent-3-en-2-one 

Relevant articles and documents

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PROCESS FOR THE CYCLOPROPANATION OF OLEFINS USING N-METHYL-N-NITROSO COMPOUNDS

A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.

A METHOD FOR THE PREPARATION OF DIAZOALKANES

The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used,