1637482-97-3

Basic information

• Product Name: N-benzyl-2-(pyrrolidin-1-yl)quinoline-6-carboxamide
• Synonyms: N-benzyl-2-(pyrrolidin-1-yl)quinoline-6-carboxamide
• CAS NO: 1637482-97-3
• Molecular Weight: 331.417
• Mol File: 1637482-97-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-(pyrrolidin-1-yl)quinoline-6-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(pyrrolidin-1-yl)quinoline-6-carboxamide(1637482-97-3)
• EPA Substance Registry System: N-benzyl-2-(pyrrolidin-1-yl)quinoline-6-carboxamide(1637482-97-3)

Safety Data

• Hazardous Substances Data: 1637482-97-3(Hazardous Substances Data)

Upstream product

• 1810-71-5 6-bromo-2-chloroquinoline 
• 1810-66-8 6-bromo-2-quinolone 
• 327058-51-5 N-(4-bromophenyl)-(E)-3-ethoxyacrylamide 
• 958332-92-8 2-(pyrrolidin-1-yl)quinoline-6-carboxylic acid 
• 100-46-9 benzylamine 

Relevant articles and documents

Synthesis and biological evaluation of 2-substituted quinoline 6-carboxamides as potential mGluR1 antagonists for the treatment of neuropathic pain

A series of 2-amino and 2-methoxy quinoline-6-carboxamide derivatives have been synthesized and their metabotropic glutamate receptor type 1 (mGluR1) antagonistic activities were evaluated in a functional cell-based assay. The compound 13c showed the highest potency with IC50 value of 2.16μM against mGluR1. Finally, in vivo evaluation of 13c in the rat spinal nerve ligation (SNL) model exhibited weak analgesic effects with regard to both mechanical allodynia and cold allodynia.