1638-22-8

Basic information

• Product Name: 4-Butylphenol
• Synonyms: 1-(p-Hydroxyphenyl)butane;1-Hydroxy-4-n-butylbenzene;4-butyl-pheno;butylphenol;Phenol, p-butyl-;Phenol,4-butyl-;phenol,p-butyl;Phenol,p-butyl-
• CAS NO: 1638-22-8
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.22
• EINECS: 216-672-5
• Product Categories: Aromatic Phenols;Building Blocks for Liquid Crystals;Functional Materials;Phenols (Building Blocks for Liquid Crystals)
• Mol File: 1638-22-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 22°C
• Boiling Point: 138-139°C 18mm
• Flash Point: 245°C
• Appearance: /
• Density: 0,98 g/cm3
• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.5170
• PKA: 10.11±0.13(Predicted)
• Water Solubility: Not miscible with water.
• BRN: 2042120
• CAS DataBase Reference: 4-Butylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Butylphenol(1638-22-8)
• EPA Substance Registry System: 4-Butylphenol(1638-22-8)

Safety Data

• Hazard Codes: C,Xn
• Statements: 20/21/22-36/37/38-41-34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3145
• RTECS: SJ8922500
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1638-22-8(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 1638-22-8 differently. You can refer to the following data:
1. liquid
2. The butylphenols include several isomers. Solid butylphenols (28805-86-9) generally have properties similar to the above:

Uses

Different sources of media describe the Uses of 1638-22-8 differently. You can refer to the following data:
1. Intermediates of Liquid Crystals
2. 4-n-Butylphenol is used as an Intermediates of liquid Crystals.

Safety Profile

A poison. Questionable carcinogen with experimental tumorigenic v v data. When heated to decomposition it emits acrid smoke and irritating fumes. See also PHENOL and other butyl phenols.

Potential Exposure

Butylphenols may be used as intermediates in manufacturing varnish and lacquer resins; as a germicidal agent in detergent disinfectants; as a pour point depressant, in motor-oil additives; de-emulsifier for oil; soap-antioxidant, plasticizer, fumigant, and insecticide

Shipping

UN2430 Alkylphenols, solid, n.o.s. (including C2-C12 homologues), Hazard class: 8; Labels: 8— Corrosive material

Incompatibilities

Vapors may form explosive mixture with air. These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may cause the gas to ignite and explode. Heat is also generated by the acid-base reaction with bases; such heating may initiate polymerization of the organic compound. React with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock

InChI:InChI=1/C10H14O/c1-2-3-4-9-5-7-10(11)8-6-9/h5-8,11H,2-4H2,1H3

Upstream product

• 18272-84-9 4-n-butylanisole 
• 1009-11-6 1-(4-hydroxyphenyl)-butan-1-one 
• 61866-52-2 1-butenyl-4-methoxybenzene 
• 104-13-2 4-Butylaniline 
• 62-53-3 aniline 
• 109-65-9 1-bromo-butane 
• 540-38-5 p-Iodophenol 
• 108-95-2 phenol 
• 104-51-8 1-butylbenzene 
• 106-98-9 1-butylene 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 
• 4346-18-3 phenyl butanoate 
• 7647-01-0 hydrogenchloride 
• 4731-84-4 1,1-bis(4-hydroxyphenyl)-n-butane 

Downstream Products

• 109368-14-1 succinic acid mono-(4-butyl-phenyl ester) 
• 109496-40-4 glutaric acid mono-(4-butyl-phenyl ester) 
• 5530-30-3 4-butyl-2,6-di-tert-butylphenol 
• 35840-23-4 4-n-Butyl-phenyl-4'-anisoat 
• 98741-97-0 3,4-Dichlor-benzyl-thiocarbamidsaeure-<4-butyl-phenyl-ester> 
• 6162-09-0 1-(4-n-butylphenoxy)-2,3-epoxypropane 
• 611227-28-2 1-butyl-4-methoxymethoxy-benzene 
• 954371-78-9 Acetic acid (S)-1-{(2R,5R)-5-[(R)-1-acetoxy-6-(4-butyl-phenoxy)-hexyl]-tetrahydro-furan-2-yl}-6-(4-butyl-phenoxy)-hexyl ester 
• 954371-47-2 Acetic acid (R)-1-{(2R,5R)-5-[(R)-1-acetoxy-6-(4-butyl-phenoxy)-hexyl]-tetrahydro-furan-2-yl}-6-(4-butyl-phenoxy)-hexyl ester 
• 926030-16-2 (2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran 
• 926030-17-3 (2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxyhexyl]-3-(dimethylphenylsilyl)tetrahydrofuran 
• 926030-20-8 (2S,3R,5S)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[(1R)-6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran 
• 926030-11-7 (2S,3R,5S)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[(1S)-6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran 
• 926030-21-9 (2S,3R,5S)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[(1R)-6-(4-butylphenyloxy)-1-hydroxyhexyl]-3-(dimethylphenylsilyl)tetrahydrofuran 

Relevant articles and documents

Stable isotope characterization of raspberry ketone extracted from Taxus baccata and obtained by oxidation of the accompanying alcohol (betuligenol)

The natural abundance 2H NMR characterization of raspberry ketone 1 extracted from himalayan Taxus baccata and of the accompanying (R) carbinol 2 is performed and compared with that of samples of 1 obtained from 2 by oxidation with Candida boidinii and CrO3, respectively. The determination of the δ(13C) and/or δ(18O) values of the above extractive products and of benzoic acid (6) and 4-butylphenol (10), obtained from natural of synthetic 1, and of 4-phenylbutan-2-ol (8), prepared from extractive 2, allows a description of the labeling pattern of this set of products. A graph of (D/H)3/(D/H)2 vs (D/H)5/(D/H)4 (Figure 3) of the presently examined samples and of those previously characterized in the laboratory, including three commercial samples sold as natural, defines three areas, containing (a) the material of botanical origin and that produced from extractive 2 by biooxidation, (b) those produced by bioreduction of the unsaturated ketone 3, and (c) the synthetic samples.

Synthesis of 4 - n-alkyl substituted phenol method

The invention discloses a synthesis method of 4-n-alkyl substituted phenol. Under the catalysis of zinc chloride, aniline and n-alkyl alcohol with the carbon number being 4-30 react in methylbenzene or xylene to obtain the 4-n-alkyl substituted aniline, and then the 4-n-alkyl substituted aniline reacts with sodium nitrite and acid to obtain the 4-n-alkyl substituted phenol. The synthesis method is easy to implement, an intermediate directly enters the next reaction without being separated or purified, and therefore the reaction efficiency is improved. The final product is high in purity and is good in depth of parallelism when reappearing, and technological conditions are suitable for mass production.

Synthesis and catalytic activity of monobridged bis(cyclopentadienyl)rhenium carbonyl complexes

Thermal treatment of three monobridged biscyclopentadienes (C5H5)R(C5H5) [R?=?C(CH3)2 (1), C(CH2)5 (2), Si(CH3)2 (3)] with Re2(CO)10 in refluxing mesitylene gave the corresponding complexes [(η5-C5H4)2R][Re(CO)3]2 [R?=?C(CH3)2 (4), C(C5H10) (5), Si(CH3)2 (6)], which were separated by chromatography, and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The molecular structures of complexes 5 and 6 were characterized by X-ray crystal diffraction analysis and show that both are monobridged bis(cyclopentadienyl)rhenium carbonyl complexes in which the molecule consists of two [(η5-C5H4)Re(CO)3] moieties linked by a single bridge, in which each of the two Re(CO)3 units is coordinated to the cyclopentadienyl ring in an η5 mode. All three of these monobridged bis(cyclopentadienyl)rhenium carbonyl complexes have good catalytic activities in Friedel–Crafts alkylation reactions.