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1639351-92-0

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  • N-((S)-1-(((S)-1-((4-(chloromethyl)phenyl)amino)-1-oxo-5-ureidopentan- 2-yl)amino)-3-methyl-1-oxobutan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

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1639351-92-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1639351-92-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,3,9,3,5 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1639351-92:
(9*1)+(8*6)+(7*3)+(6*9)+(5*3)+(4*5)+(3*1)+(2*9)+(1*2)=190
190 % 10 = 0
So 1639351-92-0 is a valid CAS Registry Number.

1639351-92-0Downstream Products

1639351-92-0Relevant articles and documents

Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy

Wu, Chunlei,Cheng, Zhehong,Lu, Danyi,Liu, Ke,Cheng, Yulian,Wang, Pengxin,Zhou, Yimin,Li, Meiqing,Shao, Ximing,Li, Hongchang,Su, Wu,Fang, Lijing

, p. 991 - 1000 (2021/02/03)

Coibamide A (1) is a highly N-methylated cyclodepsipeptide with low nanomolar antiproliferative activities against various cancer cell lines. In previous work, we discovered a simplified analogue, [MeAla3-MeAla6]-coibamide (1a), which exhibited the same inhibitory abilities as coibamide A. Herein, to reduce the whole-body toxicity and improve the solubility of 1a, two novel peptide-drug conjugates RGD-SS-CA (2) and RGD-VC-CA (3) were designed, synthesized, and evaluated. Composed of cyclodepsipeptide 1a, a tumor-homing RGD motif, and a conditionally labile linker, the conjugates are expected to release 1a tracelessly in specific tumor microenvironments. Compared with RGD-VC-CA (3), RGD-SS-CA (2) proved to be superior in in vitro drug release and cytotoxicity tests. Notably, intravenous injection of RGD-SS-CA (2) into mice-bearing human tumor xenografts induced significant tumor growth suppression with negligible toxicity. Therefore, as a novel prodrug of the coibamide A analogue, conjugate 2 has great potential for further exploration in cancer drug discovery.

PROTEIN-ANTIVIRAL COMPOUND CONJUGATES

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Paragraph 00181; 00197-00198, (2021/07/31)

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof.

RIFAMYCIN ANALOGS AND ANTIBODY-DRUG CONJUGATES THEREOF

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, (2020/07/14)

The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureus infections). The disclosure further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific for infectious disease-related targets such as membrane glycoprotein receptor (MSR1), wall teichoic acids (WTA) or Protein A, and methods of use thereof to inhibit bacterial growth and treat bacterial infections.

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