163955-59-7

Basic information

• Product Name: 4-Keto 9-cis Retinoic Acid Methyl Ester
• Synonyms: 4-Keto 9-cis Retinoic Acid Methyl Ester;4-Oxo-9-cis-Retinoic Acid Methyl Ester
• CAS NO: 163955-59-7
• Molecular Formula: C21H28O3
• Molecular Weight: 328.44522
• Product Categories: Retinoids
• Mol File: 163955-59-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 468.054°C at 760 mmHg
• Flash Point: 202.537°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 4-Keto 9-cis Retinoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Keto 9-cis Retinoic Acid Methyl Ester(163955-59-7)
• EPA Substance Registry System: 4-Keto 9-cis Retinoic Acid Methyl Ester(163955-59-7)

Safety Data

• Hazardous Substances Data: 163955-59-7(Hazardous Substances Data)

Usage

Uses

Retinoic acid derivative.

InChI:InChI=1/C21H28O3/c1-15(8-7-9-16(2)14-20(23)24-6)10-11-18-17(3)19(22)12-13-21(18,4)5/h7-11,14H,12-13H2,1-6H3/b9-7+,11-10+,15-8-,16-14+

Upstream product

• 67-56-1 methanol 
• 302-79-4 all-trans-retinoic-acid 
• 339-16-2 all-trans-methyl retinoate 
• 81121-19-9 (2E,4E,6E,8E)-9-(3-Acetoxy-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester 
• 33532-44-4 4-keto-all-trans-retinal 
• 38030-59-0 4-Hydroxyretinoic acid methyl ester 
• 4759-48-2 13-cis-retinoic acid 
• 16760-45-5 (2Z,4E,6E,8E)-methyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate 

Downstream Products

• 1425830-36-9 C₂₀H₂₈O₃ 
• 1425830-47-2 C₂₀H₂₈O₃ 
• 81121-27-9 rac-(2E,4E,6E,8E)-3,7-dimethyl-9-<2,6-dimethyl-6-(hydroxymethyl)-3-oxo-1-cyclohexen-1-yl>-2,4,6,8-nonatetraenoic acid 
• 163808-81-9 (13E)-3,7-dimethyl-9-[(3RS)-3-methoxy-2,6,6-trimethylcyclohexenyl]-2,4,6,8-nontetraenoate methyl ester 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF 4-OXOISOTRETINOIN

The present invention relates to an improved process for the preparation of 4-Oxoisotretinoin and purification process of 4-Oxoisotretinoin (I) and crystalline 5 form of 4-Oxoisotretinoin (I).

13-CIS-RAMBA RETINAMIDES THAT DEGRADE MNKS FOR TREATING CANCER

The synthesis and in vitro and in vivo anti-breast and anti-prostate cancers activities of novel C-4 heteroaryl 13-cis retinamides that modulate Mnk-eIF4E and AR signaling are discussed. In both breast and prostate cancer cell lines, these compounds induc

Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice

Novel retinoic acid metabolism blocking agents (RAMBAs) have been synthesized and characterized. The synthetic features include introduction of nucleophilic ligands at C-4 of all-trans-retinoic acid (ATRA) and 13-cis-retinoic acid, and modification of ter