164461-17-0

Basic information

• Product Name: (R)-methyl 2-acetamido-3-(4-bromophenyl)propanoate
• Synonyms: (R)-methyl 2-acetamido-3-(4-bromophenyl)propanoate
• CAS NO: 164461-17-0
• Molecular Weight: 300.152
• Mol File: 164461-17-0.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: (R)-methyl 2-acetamido-3-(4-bromophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-acetamido-3-(4-bromophenyl)propanoate(164461-17-0)
• EPA Substance Registry System: (R)-methyl 2-acetamido-3-(4-bromophenyl)propanoate(164461-17-0)

Safety Data

• Hazardous Substances Data: 164461-17-0(Hazardous Substances Data)

Upstream product

• 35356-70-8 Methyl 2-acetamidoacrylate 
• 374564-35-9 potassium 4-bromophenyltrifluoroborate 
• 1273258-11-9 (Z)-4-(4-bromobenzylidene)-2-methyloxazol-5(4H)-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 186581-53-3 diazomethane 

Relevant articles and documents

Supramolecular chiral phosphorous ligands based on a [2]pseudorotaxane complex for asymmetric hydrogenation

A new type of supramolecular chiral phosphorus-based ligands was prepared from easily available monodentate ligands through complexation between dibenzylammonium salt and dibenzo[24]crown-8 macrocycle. Rhodium complexes with these supramolecular ligands w

Tandem 1,4-Addition/Enantioselective Protonation Catalyzed by Rhodium Complexes: Efficient Access to α-Amino Acids

Conjugate addition of potassium trifluoro(organo)borates 2 (R = aryl, alkenyl) to 2-acetamidoacrylate 1 mediated by a chiral rhodium catalyst and with in situ enantioselective protonation afforded a variety of α-amino acids 3 with high yields and ee values up to 90% (see scheme, cod = cycloocta-1,5-diene, binap = 2,2′-bis(diphenylphosphanyl)-1,1′ -binaphthyl). Among the tested chiral ligands and proton sources, binap in combination with 2-methoxyphenol (guaiacol), an inexpensive and nontoxic phenol, afforded the highest asymmetric inductions.

Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis

A small library of diaza-crown ether-bridged chiral diphosphoramidite ligands was prepared. In the rhodium-catalyzed asymmetric hydrogenation and hydroformylation reactions, these ligands exhibited distinct properties in catalytic activity and/or enantioselectivity. Hydrogenated products with opposite absolute configurations could be obtained in high yields with excellent ee values by utilizing (S,S)-L1 and (S,S)-L3, respectively. Meanwhile, the addition of alkali metal cations caused variations in catalytic outcomes, showing the supramolecular tunability of these Rh/diphosphoramidite catalytic systems.

An Atropos Chiral Biphenyl Bisphosphine Ligand Bearing Only 2,2′-Substituents and Its Application in Rh-Catalyzed Asymmetric Hydrogenation

An atropos chiral biphenyl bisphosphine ligand bearing only 2,2′-substituents was rationally designed and easily synthesized utilizing a bulky chiral t-butylmethylphosphino block. Computational results showed a large difference in the free energies betwee