16588-03-7 Usage
General Description
5-nitro-2-(phenylamino)benzonitrile is a chemical compound with the molecular formula C13H9N3O2. It is a nitrobenzonitrile derivative, which has a nitro group and a phenylamino group attached to a benzonitrile backbone. 5-nitro-2-(phenylamino)benzonitrile is often used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is known to exhibit moderate toxicological properties and caution should be exercised when handling this chemical. Additionally, research has shown that this compound may have potential applications in the field of medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 16588-03-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,8 and 8 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16588-03:
(7*1)+(6*6)+(5*5)+(4*8)+(3*8)+(2*0)+(1*3)=127
127 % 10 = 7
So 16588-03-7 is a valid CAS Registry Number.
16588-03-7Relevant articles and documents
Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides
Makosza, Mieczyslaw,Bialecki, Maciej
, p. 4878 - 4888 (2007/10/03)
A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.
