16695-22-0

Basic information

• Product Name: N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE
• Synonyms: N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE;N,N-bis(2-(P-tolylsulfonyloxy)ethyl)-P-toluenesul;N,N-bis(2-tosyloxy)ethyl)toluene-4-*sulfonamide;N,N-bis[2-(tosyloxy)ethyl]toluene-4-sulfonamide;N,N-BIS(2-(TOSYLOXY)ETHYL)-P-TOLUENE- SULFONAMIDE;N,N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide;N,O,Oμ-Tritosyldiethanolamine, N,N-Bis[2-(tosyloxy)ethyl]-p-toluenesulfonamide;N,O,Oμ-Tritosyldiethanolamine
• CAS NO: 16695-22-0
• Molecular Formula: C₂₅H₂₉NO₈S₃
• Molecular Weight: 567.69
• EINECS: 412-920-3
• Product Categories: Amino Alcohols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 16695-22-0.mol
• Article Data: 39

Chemical Properties

• Melting Point: 92-98 °C(lit.)
• Boiling Point: 732.4°Cat760mmHg
• Flash Point: 396.8°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 2.6E-21mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 2406580
• CAS DataBase Reference: N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE(16695-22-0)
• EPA Substance Registry System: N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE(16695-22-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43-53
• Safety Statements: 24-37-61
• WGK Germany: 1
• Hazardous Substances Data: 16695-22-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 16695-22-0 differently. You can refer to the following data:
1. N,N-BIS[2-(P-TOLYLSULFONYLOXY)ETHYL]-P-TOLUENESULFONAMIDE used to prepare selectively protected aza-macrocycles,1 carbon-bridged metallacarboranes,2 and tetrakis(phosphonomethyl)-substituted cyclododecanes.3
2. N,N-Bis[2-(p-tolylsulfonyloxy)ethyl]-p-toluenesulfonamide may be used in the preparation of :2-(p-benzamidobenzyl)-1,4,7-tris(p-tolylsulfonyl)-1,4,7-triazacyclononane, via reaction with N,N′-bis(p-tolylsulfonyl)-1-(p-benzamidobenzyl)ethylenediamineselectively protected aza-macrocyclescarbon-bridged metallacarboranestetrakis(phosphonomethyl)-substituted cyclododecanes

InChI:InChI=1/C25H29NO8S3/c1-20-4-10-23(11-5-20)35(27,28)26(16-18-33-36(29,30)24-12-6-21(2)7-13-24)17-19-34-37(31,32)25-14-8-22(3)9-15-25/h4-15H,16-19H2,1-3H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 111-42-2 2,2'-iminobis[ethanol] 
• 7146-67-0 N-tosyldiethanolamine 

Downstream Products

• 432-92-8 N,N-bis-(2-fluoro-ethyl)-toluene-4-sulfonamide 
• 4004-97-1 4-(4-fluorophenyl)-1-toluene-p-sulfonylpiperazine 
• 54533-67-4 1,5-bis(2-nitrophenoxy)-3-(4-toluenesulfonyl)-3-azapentane 
• 157522-22-0 N,N'-ditosylbis(2-piperazinylethyl)methylamine 
• 66977-69-3 11-benzyl-1,4,7-tris-(toluene-4-sulfonyl)-1,4,7,11-tetraaza-cyclotetradecane 
• 168279-78-5 N,N-Bis<2-(2'-formylphenoxy)ethyl>-p-toluenesulfonamide 
• 208511-31-3 N,N-bis[2-(3,5-bis(ethoxycarbonyl)phenoxy)ethyl]-p-toluene sulfonamide 
• 52601-83-9 N,N-Bis(2-iodethyl)-4-methylbenzolsulfonamid 
• 613668-24-9 (R,R)-2,5,8-tris(p-tolylsulfonyl)-2,5,8-triazabicyclo<7.4.0^1,9>tridecane 
• 929078-51-3 (S,S)-2,5,8-tris(p-tolylsulfonyl)-2,5,8-triazabicyclo<7.4.0^1,9>tridecane 
• 155330-74-8 C₂₃H₂₅NO₈S₃ 
• 17046-84-3 1,4-bis-(toluene-4-sulfonyl)-piperazine 
• 52667-88-6 cyclen tetratosylate 
• 52667-89-7 N,N',N-tris(p-toluenesulfonyl)-1,4,7-triazacyclononane 

Relevant articles and documents

α-Glucosidase inhibition and antihyperglycemic activity of flavonoids from Ampelopsis grossedentata and the flavonoid derivatives

The dried leaves and stems of Ampelopsis grossedentata have been used as a health tea and herbal medicine for hundreds of years in China. The study was aimed at searching for novel α-glucosidase inhibitors among the richest components of A. grossedentata and their derivatives. Three known major components (1-3) were isolated by recrystallization process and six new derivatives (4-9) were obtained by etherification of the bioactive flavonoid. All compounds were evaluated for their inhibitory activities against α-glucosidase (from Saccharomyces cerevisiae). As a result, compound 9 showed a significant α-glucosidase inhibitory activity with IC50 value of 9.3 μM and acted as a competitive inhibitor with the value of the inhibition constant (Ki) being 10.3 μM. The oral administration of compound 9 at a dose of 50 mg/kg significantly reduced the post prandial blood glucose levels of normal and streptozotocin (STZ)-induced diabetic mice. Furthermore, compound 9 significantly decreased the fasting blood glucose levels in STZ-induced diabetic mice.

Impact of N-substituents on crystal packing of N-alkyl-N′-tosylpiperazines and development of new polymorph of tosylbis(2-(tosyloxy)ethyl)amine: Synthesis, DFT, photophysical, cytotoxic property

Diethanol amine (DEA) was selected as a lead compound to prepare N-tosyldiethanol amine 1, N-tosylbis(2-(tosyloxy)ethyl)amine 2 and disubstituted piperazines ca N-alkyl-N′-tosylpiperazines 3–5 in high yield. The new compounds were characterized by using relevant techniques viz. MS, IR, 1H, 13C, DEPT 135 NMR, UV–vis. absorption and fluorescence spectral studies. Single crystal X-ray diffraction technique was used to detect a new polymorphic form of 2 and to measure the influence of various N-substituents on the association of molecules of 3–5 in the solid state. Evidently, the introduction of N-cyclohexyl substituent in 3 successfully switches off all the synthons ca CH…O and CH…N seen in compound 4 and 5. Compounds 4 and 5 holding N-furfuryl and N-benzyl substituents, respectively, adopt other packing strategies based on CH…O, CH…N (4) and CH…O (5) interactions. The antitumor activity of 1–5 was evaluated in vitro against Hep 3B and IMR 32 by the MTT assay and the results were compared with cisplatin. Remarkably, some compounds were found extremely active against both the cell lines and proved to be more potent as cytotoxic agents than cisplatin. Density functional theory and molecular docking studies have been performed to rationalize the experimental results.

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

To provide a metal complex that has high cancer cell toxicity and has DNA target and cyclen.SOLUTION: The present disclosure provides a dinuclear metal complex represented by the following formula (IV).SELECTED DRAWING: None

BINUCLEATING LIGAND OR BINUCLEAR METAL COMPLEX

PROBLEM TO BE SOLVED: To provide a binuclear metal complex that can be easily synthesized and has a proper anticancer action. SOLUTION: The present invention provides a binuclear metal complex represented by the following chemical formula (IV). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT