16719-46-3 Usage
Uses
Used in Pharmaceutical Industry:
5'-TUMP SODIUM SALT is used as an active pharmaceutical ingredient for its potential therapeutic effects. The compound's unique structure allows it to interact with specific biological targets, making it a promising candidate for the development of new drugs.
Used in Research and Development:
In the field of research and development, 5'-TUMP SODIUM SALT serves as a valuable tool for studying the mechanisms of various biological processes. Its unique properties enable scientists to investigate the roles of ribonucleoside monophosphates in cellular functions and their potential as therapeutic agents.
Used in Diagnostic Applications:
5'-TUMP SODIUM SALT can be employed as a diagnostic agent, particularly in the detection and monitoring of certain diseases or conditions. Its specific interactions with biological targets can be exploited to develop assays and tests that help in the early diagnosis and treatment of various health issues.
Used in Biochemical Studies:
5'-TUMP SODIUM SALT is used as a research compound in biochemical studies, where it can help researchers understand the roles of ribonucleoside monophosphates in cellular metabolism and other biological processes. This knowledge can contribute to the development of novel therapeutic strategies and interventions.
Used in Drug Design and Synthesis:
In the field of drug design and synthesis, 5'-TUMP SODIUM SALT serves as a key building block or precursor for the development of new pharmaceuticals. Its unique structure and properties can be utilized to create innovative drug candidates with potential applications in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 16719-46-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,1 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16719-46:
(7*1)+(6*6)+(5*7)+(4*1)+(3*9)+(2*4)+(1*6)=123
123 % 10 = 3
So 16719-46-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N4O7P/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(17)7(16)6(22-11)3-21-23(18,19)20/h1-2,4,6-8,11,16-17H,3H2,(H2,12,13,14)(H2,18,19,20)/t6-,7-,8-,11-/m1/s1
16719-46-3Relevant articles and documents
Variable-Temperature NMR Spectroscopy, Conformational Analysis, and Thermodynamic Parameters of Cyclic Adenosine 5′-Diphosphate Ribose Agonists and Antagonists
Saatori, Sarah-Marie,Perez, Tanner J.,Graham, Steven M.
, p. 2554 - 2569 (2018)
Cyclic adenosine 5′-diphosphate ribose (cADPR) is a ubiquitous Ca2+-releasing second messenger. Knowledge of its conformational landscape is an essential tool for unraveling the structure-activity relationship (SAR) in cADPR. Variable-temperature 1H NMR spectroscopy, in conjunction with PSEUROT and population analyses, allowed us to determine the conformations and thermodynamic parameters of the furanose rings, γ-bonds (C4′-C5′), and β-bonds (C5′-O5′) in the cADPR analogues 2′-deoxy-cADPR, 7-deaza-cADPR, and 8-bromo-cADPR. A significant finding was that, although the analogues are similar to each other and to cADPR itself in terms of overall conformation and population (ΔG°), there were subtle yet important differences in some of thermodynamic properties (ΔH°, ΔS°) associated with each of the conformational equilibria. These differences prompted us to propose a model for cADPR in which the interactions between the A2′-N3, A5″-N3, and H2-R5′ atoms serve to fine-tune the N-glycosidic torsion angles (χ).
