16760-45-5

Basic information

• Product Name: methyl (2Z,4E,6Z,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)no na-2,4,6,8-tetraenoate
• Synonyms: methyl (2Z,4E,6Z,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)no na-2,4,6,8-tetraenoate
• CAS NO: 16760-45-5
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.46
• Product Categories: Retinoids
• Mol File: 16760-45-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 426.1°Cat760mmHg
• Flash Point: 229.8°C
• Appearance: /
• Density: 0.975g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Amber Vial, -86°C Freezer
• Stability: At 00C.
• CAS DataBase Reference: methyl (2Z,4E,6Z,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)no na-2,4,6,8-tetraenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2Z,4E,6Z,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)no na-2,4,6,8-tetraenoate(16760-45-5)
• EPA Substance Registry System: methyl (2Z,4E,6Z,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)no na-2,4,6,8-tetraenoate(16760-45-5)

Safety Data

• Hazardous Substances Data: 16760-45-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

Retinoic acid derivative.

InChI:InChI=1/C21H30O2/c1-16(9-7-10-17(2)15-20(22)23-6)12-13-19-18(3)11-8-14-21(19,4)5/h7,9-10,12-13,15H,8,11,14H2,1-6H3/b10-7+,13-12+,16-9+,17-15-

Upstream product

• 186581-53-3 diazomethane 
• 4759-48-2 13-cis-retinoic acid 
• 22030-20-2 (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-1-ol 
• 43059-51-4 (2E,6E,8E)-5-Acetoxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienoic acid methyl ester 
• 85329-44-8 Acetic acid 5,9-bis-benzenesulfonyl-3,7-dimethylene-1-phenylsulfanyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nonyl ester 
• 85329-43-7 C₃₈H₄₆O₅S₃ 
• 85329-42-6 C₃₈H₄₆O₄S₃ 
• 85329-45-9 5,9-Bis-benzenesulfonyl-3,7-dimethylene-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nonan-1-ol 
• 85329-38-0 C₂₂H₂₅ClO₂S₂ 
• 85329-36-8 4-Benzenesulfonyl-2,6-dimethylene-8-phenylsulfanyl-octan-1-ol 
• 90105-85-4 (2E,6E)-9-Benzenesulfonyl-8-hydroxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienoic acid methyl ester 
• 90083-48-0 methyl 3,7-dimethyl-8-formyl-2,6-octadienoate 
• 56691-74-8 {[(2,6,6-trimethyl-1-cyclohexen-1-yl)methyl]sulfonyl}benzene 
• 90083-47-9 (2E,6E)-9-Benzenesulfonyl-3,7-dimethyl-8-(tetrahydro-pyran-2-yloxy)-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienoic acid methyl ester 

Downstream Products

• 4759-48-2 13-cis-retinoic acid 
• 472-86-6 13-cis-vitamin A aldehyde 

Relevant articles and documents

Assignment of 1H and 13C NMR Spectra of Retinoic Acid Ester Isomers Observed in the Long-Wavelength UV-Induced Photostationary State

1H and 13C chemical shift assignments, obtained with the aid of two-dimensional hetenuclear shift correlation and double-quantum coherence 13C-INADEQUATE experiments, are reported for four retinoic acid ester isomers observed at the photostationary state.Also detailed are 1H assignments for three additional isomers obtained in insufficient amounts for 13C measurements.KEY WORDS - Retionic acid esters Isomer identification 1H-13C correlation spectra 13C-INADEQUATE experiment

13-CIS-RAMBA RETINAMIDES THAT DEGRADE MNKS FOR TREATING CANCER

The synthesis and in vitro and in vivo anti-breast and anti-prostate cancers activities of novel C-4 heteroaryl 13-cis retinamides that modulate Mnk-eIF4E and AR signaling are discussed. In both breast and prostate cancer cell lines, these compounds induc

Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice

Novel retinoic acid metabolism blocking agents (RAMBAs) have been synthesized and characterized. The synthetic features include introduction of nucleophilic ligands at C-4 of all-trans-retinoic acid (ATRA) and 13-cis-retinoic acid, and modification of ter