168428-76-0

Basic information

• Product Name: 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE
• Synonyms: 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE;4-CHLORO-N,N-DIISOPROPYLPICOLINAMIDE;4-chloro-N,N-bis(propan-2-yl)pyridine-2-carboxaMide
• CAS NO: 168428-76-0
• Molecular Formula: C₁₂H₁₇ClN₂O
• Molecular Weight: 240.72918
• Product Categories: Pyridines
• Mol File: 168428-76-0.mol

Chemical Properties

• Boiling Point: 361.3 °C at 760 mmHg
• Flash Point: 172.3 °C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE(168428-76-0)
• EPA Substance Registry System: 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE(168428-76-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 168428-76-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE is used as a chemical intermediate in the synthesis of various drugs and agrochemicals. Its unique structure and functional groups make it a valuable building block for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE serves as a versatile intermediate for the preparation of a wide range of chemical compounds. Its reactivity and functional group compatibility allow for the synthesis of various target molecules with potential applications in different industries.
Used in Drug Development:
4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE is used as a starting material for the development of new therapeutic agents. Its biological activities and potential as a lead compound make it a promising candidate for further research and optimization in drug discovery processes.
Used in Agrochemicals:
In the agrochemical industry, 4-CHLORO-N-DIISOPROPYL-PYRIDINE-2-CARBOXAMIDE is used as an intermediate for the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique properties and reactivity contribute to the development of effective and environmentally friendly solutions for agricultural applications.

InChI:InChI=1/C12H17ClN2O/c1-8(2)15(9(3)4)12(16)11-7-10(13)5-6-14-11/h5-9H,1-4H3

Upstream product

• 5470-22-4 4-chloropicolinic acid 
• 446019-92-7 4-chloro-3-iodo-pyridine-2-carboxylic acid diisopropylamide 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 108-18-9 diisopropylamine 

Downstream Products

• 1310055-85-6 C₁₉H₂₃ClN₂OSe 
• 913696-69-2 4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-N,N-diisopropylpyridine-2-carboxamide 
• 446019-94-9 4-methoxy-2-pyridine carboxylic acid N,N-diisopropylamide 

Relevant articles and documents

Total synthesis of caerulomycin C via the halogen dance reaction.

[reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

Benzimidazole compound

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.