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16851-56-2

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16851-56-2 Usage

General Description

Indoline-2-carboxylic acid is an organic compound with the chemical formula C9H9NO2. It is a derivative of indole, a heterocyclic aromatic compound. Indoline-2-carboxylic acid is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has been studied for its potential pharmacological properties, including its antimicrobial and anti-inflammatory effects. The compound has also been investigated for its potential use in organic electronics and as a fluorescent probe in biological imaging. Overall, indoline-2-carboxylic acid has a range of applications in various fields due to its unique chemical structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 16851-56-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,5 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16851-56:
(7*1)+(6*6)+(5*8)+(4*5)+(3*1)+(2*5)+(1*6)=122
122 % 10 = 2
So 16851-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/p-1/t8-/m1/s1

16851-56-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Indoline-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2-indolinecarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16851-56-2 SDS

16851-56-2Relevant articles and documents

Preparation method and application of hydrazide indoles drugs

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Paragraph 0037; 0038; 0041, (2017/08/28)

The invention provides a preparation method and application of hydrazide indoles drugs, and discloses a 2-hydrazide substituted indole compound and a preparation method and application thereof. The novel 2-hydrazide substituted indole compound has quite high activity of inhibiting growth of tumor cells, and particularly has remarkable inhibiting effect on growth of human rectal cancer cells and colon cancer cells which have vascular endothelial growth factor receptor-2 subtype high expression; the IC50 value of the novel 2-hydrazide substituted indole compound can be about 10 mu M; the novel 2-hydrazide substituted indole compound has good antiangiogensis activity on a CAM (chick chorioallantoic membrane) model; and moreover, the compound 21 has good capability of resisting cell proliferation after HUVEC is stimulated by VEGF and specificity of resisting proliferation after HUVEC is simulated by VEGF.

Novel method for the synthesis of s-indoline-2- carboxylic acid and application thereof in the synthesis of perindopril

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Page/Page column 3, (2008/06/13)

Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.

PROCESS AND PRODUCT

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Page 7; 22; scheme, (2010/02/09)

A process of preparing perindopril of formula (I), or a pharmaceutically acceptable salt thereof which process comprises protecting a compound of formula (II) where R denotes a hydrogen atom, in the presence of benzene sulphonic acid as a catalyst, to obtain the benzene sulphonic acid salt of an ester of formula (III) where Rl is a carboxyl protecting group and reacting said ester of formula (III) with N-[(S)-1-carbethoxybutyl]-(S)-alanine to obtain a compound of formula (IV) where Rl is as defined above; and deprotecting a compound of formula (IV) to yield perindopril of formula (I), or a pharmaceutically acceptable salt thereof. There is also provided by the present invention the benzene sulphonic acid salt of an ester of formula (III), and perindopril or a pharmaceutically acceptable salt thereof prepared by the above process.

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