16867-03-1Relevant articles and documents
Synthesis method of 2-amino-3-hydroxypyridine
-
Paragraph 002; 0024-0025; 0028-0029; 0032-0033; 0036-0037, (2021/03/31)
The invention discloses a synthesis method of 2-amino-3-hydroxypyridine, which comprises the following steps: reacting furfural serving as a raw material with haloid and sulfamate in an acid water solution to obtain 2-imino-3-hydroxypyridine sulfonic acid, and heating and hydrolyzing the 2-imino-3-hydroxypyridine sulfonic acid to obtain 2-amino-3-hydroxypyridine sulfate; and finally, adjusting thepH value by using alkali to obtain the 2-amino-3-hydroxypyridine. By using the method provided by the invention, the product yield is high, furfural which is cheap and easy to obtain is used as a rawmaterial, substances with higher toxicity are prevented from being used in the production process, the reaction condition is mild and no waste gas is generated in the reaction process; the solutionsof the method are all aqueous solution, and wastewater generated in the production process is a halite solution and a sulfate solution, which can be marketed as byproducts; the method reduces enterprise three-waste treatment cost, changes wastes into valuables, reduces environmental pollution from the source, reduces enterprise production cost and improves income.
Hexafluoro-2-propanol-assisted quick and chemoselective nitro reduction using iron powder as catalyst under mild conditions
Chen, Xu-Ling,Ai, Bai-Ru,Dong, Yu,Zhang, Xiao-Mei,Wang, Ji-Yu
supporting information, p. 3646 - 3649 (2017/08/23)
Hexafluoro-2-propanol as the promoter for the quick nitro reduction using a combination of iron powder and 2 N HCl aqueous solution is reported. This methodology has several positive features, as it is of room temperature, remarkably short reaction time. A wide range of substrates including those bearing reducible functional groups such as aldehyde, ketone, acid, ester, amide, nitrile, halogens, even allyl, propargyl and heterocycles are chemoselectively reduced in good to excellent yields, even on gram scale. Notably, the highly selective reduction of 3-nitrophenylboronic acid is achieved quantitatively. The reduction is also tolerant of common protecting groups, and aliphatic nitro compound, 1-nitrooctane can be reduced successfully.
Transfer hydrogenation of nitroarenes to arylamines catalysed by an oxygen-implanted MoS2 catalyst
Zhang, Chaofeng,Zhang, Zhixin,Wang, Xu,Li, Mingrun,Lu, Jianmin,Si, Rui,Wang, Feng
, p. 85 - 93 (2016/07/25)
We present an efficient approach for chemoselective synthesis of various functionalized arylamines from nitroarenes over an oxygen-implanted MoS2 catalyst (O-MoS2). The HRTEM, XRD, XPS, Raman, EXAFS and NH3-TPD characterizations show the existence of MoIVOx structure and abundant coordinative unsaturated (CUS) Mo sites in the 2D-layer structure of O-MoS2. In the transfer hydrogenation of nitroarenes with hydrazine hydrate, the MoIVOx structure works as the catalytic active center. The N2H4 selectively decomposes to the active hydrogen species in polar electronic states (Hδ? and Hδ+), which show high chemoselectivity toward the nitro reduction over [Formula presented], [Formula presented], and [Formula presented] groups. The O-MoS2 catalyst can be recovered in a facile manner from the reaction mixture and recycled four times without any significant loss of activity.