169463-44-9

Basic information

• Product Name: 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylic acid, 5-cyano-
• CAS NO: 169463-44-9
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.17
• Mol File: 169463-44-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 509.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.16±0.30(Predicted)
• CAS DataBase Reference: 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID(169463-44-9)
• EPA Substance Registry System: 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID(169463-44-9)

Safety Data

• Hazardous Substances Data: 169463-44-9(Hazardous Substances Data)

Usage

General Description

5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C10H7NO2. It belongs to the class of organic compounds known as indole carboxylic acids. 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceuticals. It is also used as a building block in the production of other organic compounds. 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID has a wide range of applications in the fields of medicine and chemical synthesis, making it an important and versatile chemical compound.

Upstream product

• 169463-42-7 (5-cyano-2-nitro-phenyl)-pyruvic acid ethyl ester 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 127-17-3 2-oxo-propionic acid 
• 33348-34-4 4-amino-3-iodobenzonitrile 
• 105191-13-7 5-Cyano-1H-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 186430-01-3 5-Cyano-1H-indole-2-carboxylic acid ((1S)-benzyl-2-oxo-2-thiazolidin-3-yl-ethyl)-amide 
• 1228694-01-6 methyl (S)-5-(benzyloxy)-1-(chloromethyl)-3-(5-cyanoindole-2-carbonyl)-1,2-dihydropyrrolo[3,2-e]indole-2-carboxylate 
• 105191-13-7 5-Cyano-1H-indole-2-carboxylic acid ethyl ester 
• 1027371-97-6 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester 
• 1027262-37-8 7-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-3-phenyl-heptanoic acid tert-butyl ester 
• 199609-35-3 5-(Benzyloxycarbonylamino-imino-methyl)-1H-indole-2-carboxylic acid ethyl ester 
• 199609-30-8 5-(Benzyloxycarbonylamino-imino-methyl)-1H-indole-2-carboxylic acid 

Relevant articles and documents

Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5′ position of the DNA binding subunit, are described.

COMPOUNDS

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.