1697-34-3

Basic information

• Product Name: 4-Methanesulfonyl morpholine
• Synonyms: 4-Methanesulfonyl morpholine;4-(METHYLSULFONYL)MORPHOLINE
• CAS NO: 1697-34-3
• Molecular Formula: C₅H₁₁NO₃S
• Molecular Weight: 165.21074
• Mol File: 1697-34-3.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Methanesulfonyl morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methanesulfonyl morpholine(1697-34-3)
• EPA Substance Registry System: 4-Methanesulfonyl morpholine(1697-34-3)

Safety Data

• Hazardous Substances Data: 1697-34-3(Hazardous Substances Data)

Usage

General Description

4-Methanesulfonyl morpholine is a chemical compound with the molecular formula C5H11NO3S. It is an organic compound that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. Its main use is as a reagent in the synthesis of sulfonyl chlorides and sulfonamides. It is a clear, colorless to pale yellow liquid with a faint, sweet odor. It is considered to be stable under normal conditions and is not highly reactive. However, it should be handled and stored with care, as it can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. It is also important to note that 4-Methanesulfonyl morpholine is not listed as a substance of concern by any major regulatory body.

Upstream product

• 110-91-8 morpholine 
• 124-63-0 methanesulfonyl chloride 
• 10383-49-0 methyl α-disulfone 
• 80284-02-2 N-nitromethanesulfonimide 
• 4837-30-3 1-(methylthio)morpholine 
• 20277-69-4 sodium methansulfinate 
• 13368-42-8 4-(trimethylsilyl)morpholine 
• 558-25-8 methyl fluorosulfonate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 110417-55-5 N-[(2-Phenyloxo-2-ethane)sulphonyl]morpholine 
• 130178-99-3 1-(2,4-Dichloro-phenyl)-2-(morpholine-4-sulfonyl)-ethanone 
• 130179-01-0 2-(Morpholine-4-sulfonyl)-1-(4-trifluoromethyl-phenyl)-ethanone 
• 130179-04-3 2-(Morpholine-4-sulfonyl)-1-(4-nitro-phenyl)-ethanone 
• 1026484-23-0 1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone 
• 202286-54-2 9-isopropyl-7,12-dimethyl-3-(morpholinosulfonyl)benzo[a]heptalene-2,4-diol 
• 92-52-4 biphenyl 
• 19158-31-7 4-(phenylmethane)sulfonylmorpholine 
• 130178-85-7 4-[2-(4-Trifluoromethyl-phenyl)-ethynesulfonyl]-morpholine 
• 130178-88-0 4-[2-(4-Nitro-phenyl)-ethynesulfonyl]-morpholine 
• 130178-83-5 4-[2-(2,4-Dichloro-phenyl)-ethynesulfonyl]-morpholine 
• 130178-89-1 Dimethyl-[4-(morpholine-4-sulfonylethynyl)-phenyl]-amine 
• 130178-86-8 4-[2-(4-tert-Butyl-phenyl)-ethynesulfonyl]-morpholine 
• 130178-87-9 4-[2-(4-Methoxy-phenyl)-ethynesulfonyl]-morpholine 

Relevant articles and documents

Electrosynthesis of sulfonamides from DMSO and amines under mild conditions

With DMSO as the solvent and the precursor of a -SO2Me unit at room temperature, a novel electrochemical oxidization and amination of DMSO with amines was developed for the synthesis of sulfonamides. Our investigations reveal that this transformation may involve a radical process and an electrochemical oxidization of DMSO.

Process for the Synthesis of Sulfones and Sulfonamides

A one pot single step process is described for the synthesis of a compound, including a labeled compound, containing a sulfonyl functional group comprising the step of mixing together a silane, an SO2 source, an electrophilic compound, an activ

Iodine-catalyzed oxidative amination of sodium sulfinates: A convenient approach to the synthesis of sulfonamides under mild conditions

The iodine-catalyzed oxidative amination of sodium sulfinates in the presence of sodium percarbonate as the oxidant has been developed. The reaction shows good substrate scope and tolerates a wide range of functionalities in both amine and sodium sulfinate substrates. Aliphatic amines, heteroaromatic amines and hydrochloride salts of amines canbe employed as the amine sources in this transformation. Mechanistic studies indicated that a radical pathway might be involved in the reaction process. This transition-metalfree protocol offers an alternative and convenient approach for a preparation of a series of sulfonamides in moderate to good yields under mild conditions.