17046-84-3

Basic information

• Product Name: 1,4-Ditosylpiperazine
• Synonyms: 1,4-Bis[(4-methylphenyl)sulfonyl]piperazine;1,4-Ditosylpiperazine;Nsc37244;Piperazine, 1,4-bis[(4-methylphenyl)sulfonyl]-
• CAS NO: 17046-84-3
• Molecular Formula: C₁₈H₂₂N₂O₄S₂
• Molecular Weight: 394.52
• Mol File: 17046-84-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 565.8°Cat760mmHg
• Flash Point: 296°C
• Appearance: /
• Density: 1.334g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,4-Ditosylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Ditosylpiperazine(17046-84-3)
• EPA Substance Registry System: 1,4-Ditosylpiperazine(17046-84-3)

Safety Data

• Hazardous Substances Data: 17046-84-3(Hazardous Substances Data)

Usage

General Description

1,4-Ditosylpiperazine is a chemical compound consisting of a piperazine ring with two tosyl (or toluenesulfonyl) groups attached at the 1 and 4 positions. It is used as a versatile intermediate in the synthesis of pharmaceuticals and other organic compounds. 1,4-Ditosylpiperazine has strong nucleophilic reactivity, making it useful in the formation of carbon-carbon and carbon-nitrogen bonds. It is also used as a reagent in the preparation of various heterocyclic compounds and can be employed in the synthesis of complex molecules with specific biological activities. In addition, 1,4-Ditosylpiperazine has been investigated for its potential as a precursor in the development of new drug candidates and has shown promise in the treatment of various diseases and medical conditions.

Upstream product

• 110-85-0 piperazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 1243273-34-8 N,N'-di(p-toluenesulfonyl)-N-[2-[(o-nitrophenyl)(p-toluenesulfonyl)amino]ethyl]-1,2-ethylenediamine 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 18522-92-4 sodium p-toluenesulfonamide 
• 107-06-2 1,2-dichloro-ethane 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 70-55-3 toluene-4-sulfonamide 
• 99142-37-7 N-<2-p-Toluolsulfonyloxy-ethyl>-N,N'-di-p-toluolsulfonyl-ethylendiamin 
• 1074-82-4 potassium phtalimide 
• 4403-78-5 ditosylethylenediamine 
• 19263-21-9 2-bromoethyl p-toluenesulfonate 
• 23545-41-7 N-(2-bromo-ethyl)-ethylenediamine; dihydrobromide 
• 106-93-4 ethylene dibromide 

Downstream Products

• 110-85-0 piperazine 

Relevant articles and documents

Aryl(sulfonyl)amino group: A convenient and stable yet activated modification of amino group for its intramolecular displacement

Aryl(sulfonyl)amino groups, readily derived from sulfonyl- or arylamines by standard methods as well as the recently introduced methods of sulfonylation and arylation, proved to be good leaving groups in intramolecular substitution reactions by various nitrogen, oxygen, and carbon nucleophiles.

Microwave-assisted synthesis of 1,4,7,10-tetraazacyclododecane

Tosylated cyclen is synthesized by the condensation of tritosylated diethanolamine and tosylamide monosodium salt under microwave irradiation, which, on detosylation with HBr, gives cyclen dihydrobromide. X-ray crystal structure of cyclen dihydrobromide i

N-(ω-TOSYLOXYALKYL)PHTHALIMIDES AS REACTIVE GENERAL SYNTHONS FOR INTRODUCING ALKYLAMINO GROUPS AND THEIR APPLICATION FOR THE "SELF-PROLIFERATIVE" SYNTHESIS OF OPEN-CHAIN POLYAMINES

New synthetic routes to N-(ω-tosyloxyalkyl)phthalimides (2) were developed and the synthetic utility of 2 as alkylating reagents was exemplified in the open-chain polyamine synthesis involving the "self-proliferative" process.