17059-59-5

Basic information

• Product Name: 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione
• Synonyms: 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione;1-(4-CHLOROPHENYL)-3-PHENYL-1,3-PROPANEDIONE
• CAS NO: 17059-59-5
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.7
• Mol File: 17059-59-5.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 425.5°Cat760mmHg
• Flash Point: 179.6°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 1.9E-07mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione(17059-59-5)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione(17059-59-5)

Safety Data

• Hazardous Substances Data: 17059-59-5(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione, also known as 4'-chlorocinnamoylacetic acid, is a chemical compound with the molecular formula C15H11ClO2. It is a yellow crystalline powder that is often used in the synthesis of pharmaceuticals and organic compounds. 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione has potential applications in the pharmaceutical industry due to its ability to inhibit certain enzymes and its anti-inflammatory properties. It may also be used in the production of dyes, fragrances, and other organic materials. Additionally, it is important to handle this compound with care as it is considered to be potentially harmful if ingested, inhaled, or absorbed through the skin. Overall, 1-(4-chlorophenyl)-3-phenyl-propane-1,3-dione is an important chemical compound with various potential applications in the pharmaceutical and organic chemistry industries.

InChI:InChI=1/C15H11ClO2/c16-13-8-6-12(7-9-13)15(18)10-14(17)11-4-2-1-3-5-11/h1-9H,10H2

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 99-91-2 para-chloroacetophenone 
• 93-99-2 benzoic acid phenyl ester 
• 956-02-5 4'-chlorochalcone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 98-88-4 benzoyl chloride 
• 16616-42-5 p-chlorobenzoylphenylacetylene 
• 623-03-0 4-Cyanochlorobenzene 
• 70-11-1 α-bromoacetophenone 
• 100-47-0 benzonitrile 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 93-89-0 benzoic acid ethyl ester 
• 38895-95-3 p-chlorochalcone dibromide 

Downstream Products

• 75371-69-6 (Z)-3-(4-tolylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one 
• 75371-70-9 (Z)-3-(p-chlorophenylamino)-1-(p-chlorophenyl)-3-phenyl-prop-2-en-1-one 
• 71982-96-2 (Z)-3-(4-methoxyphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one 
• 57736-13-7 2-(4'-chlorophenyl)-3-benzoyl-4-phenyl-1-oxa-4-azabutadiene 
• 75371-68-5 (Z)-1-(4-chlorophenyl)-3-phenyl-3-(phenylamino)prop-2-en-1-one 
• 85231-85-2 (4-Chloro-phenyl)-(4-phenyl-[1,2,5]thiadiazol-3-yl)-methanone 
• 85231-86-3 [4-(4-Chloro-phenyl)-[1,2,5]thiadiazol-3-yl]-phenyl-methanone 
• 1148-87-4 5-(4-chlorophenyl)-3-phenylisoxazole 
• 24097-17-4 3-(4-chlorophenyl)-5-phenylisoxazole 
• 65182-60-7 2-(4-chlorophenyl)-1,8-naphthyridine 
• 116625-81-1 (4-Chloro-phenyl)-(2-phenyl-[1,8]naphthyridin-3-yl)-methanone 
• 25352-03-8 1-(4-chlorophenyl)-2-diazo-3-phenylpropane-1,3-dione 
• 54458-29-6 2-bromo-1-(4-chlorophenyl)-3-phenyl-1,3-propanedione 
• 54458-32-1 1-(4-chlorophenyl)-3-phenylpropane-1,2,3-trione 

Relevant articles and documents

Photocatalytic ring opening of α-epoxyketones in cyclopentanone

Electron transfer-induced ring opening of α-epoxyketones by 2,4,6-triphenylpyrylium tetrafluoroborate (TPT) in cyclopentanone resulted in the diastereoselective formation of 2,5-dioxaspiro[4,4]- nonanes through Cα-O bond cleavage and following nucleophilic attack of cyclopentanone to radical cation intermediates. The readiness for ring opening is influenced by the nature and the location of the additional substituent on the α-epoxyketones.

A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol

Here, we report a metal-free approach for the construction of methylene-bridged bis-1,3-dicarbonyl compounds via cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol. In addition, we have extended this methodology to synthesize tetra-substituted pyridine derivatives using 1,3-dicarbonyl, 2-methoxyethanol and NH4OAc in one step. The key advantages include accepting a wide range of substrates, utilizing O2 as the sole oxidant, and synthesizing biologically active compounds such as 1,4-dihydropyridine and pyrazole. This journal is

Method for synthesizing 1, 3-dicarbonyl compound based on terminal alkyne and acyl halide by one-pot process

The invention belongs to the technical field of catalytic synthesis, and discloses a method for synthesizing a 1, 3-dicarbonyl compound by a one-pot process, and the method comprises the following steps: by using simple palladium and copper salts as catalysts, reacting terminal alkyne with acyl halide at 0-80 DEG C for 0.5-12 hours under the action of trifluoromethanesulfonic acid to obtain the 1,3-dicarbonyl compound, wherein the molar ratio of the terminal alkyne to the acyl halide to the palladium salt to the copper salt to the trifluoromethanesulfonic acid is 1 to (1 to 2) to (0.00001 to0.10) to (0.00001 to 0.10) to (0.00004 to 0.40); the catalysts used in the method are common the commercialized palladium salt and copper salt, reagents used in the reaction are commercialized reagents, in addition, the raw materials are cheap and easy to obtain, functional group tolerance is good, reaction conditions are mild, operation is easy and convenient, and atom economy is high.

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.