17200-29-2

Basic information

• Product Name: 5-CHLOROBENZOXAZOLE
• Synonyms: 5-CHLOROBENZOXAZOLE;5-chloro-benzoxazol;5-Chlorobenzoxazole,98%;NSC 24984;5-chlorobenzo[d]oxazole;5-Chlorobenzoxazole,95%
• CAS NO: 17200-29-2
• Molecular Formula: C₇H₄ClNO
• Molecular Weight: 153.57
• Product Categories: Oxazole&Isoxazole;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Oxazoles;OxazolesHeterocyclic Building Blocks
• Mol File: 17200-29-2.mol
• Article Data: 31

Chemical Properties

• Melting Point: 42-46 °C
• Boiling Point: 226.3±13.0℃ (760 torr)
• Flash Point: 90.7±19.8℃
• Appearance: /
• Density: 1.377±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.124mmHg at 25°C
• Refractive Index: 1.5618 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -0.85±0.10(Predicted)
• CAS DataBase Reference: 5-CHLOROBENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROBENZOXAZOLE(17200-29-2)
• EPA Substance Registry System: 5-CHLOROBENZOXAZOLE(17200-29-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: DM4690000
• Hazardous Substances Data: 17200-29-2(Hazardous Substances Data)

Usage

Chemical Properties

yellowish-orange crystalline chunks

InChI:InChI=1/C7H4ClNO/c8-5-1-2-7-6(3-5)9-4-10-7/h1-4H

Upstream product

• 123-39-7 N-Methylformamide 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 149-73-5 trimethyl orthoformate 
• 122-51-0 orthoformic acid triethyl ester 
• 61-80-3 zoxazolamine 

Downstream Products

• 1158999-45-1 5-chloro-2-(phenylthio)benzo[d]oxazole 
• 16715-75-6 2-(4-methylphenyl)-5-chlorobenzoxazole 
• 1207429-58-0 5-chloro-2-(3-(trifluoromethyl)phenyl)benzo[d]oxazole 
• 378762-37-9 5-chloro-2-(3-methoxyphenyl)benzo[d]oxazole 
• 955-77-1 5-chloro-2-(4-chlorophenyl)-1,3-benzoxazole 
• 86984-34-1 5-chloro-2-(4-methoxycarbonylphenyl)benzo[d]oxazol 
• 102394-34-3 2-benzyl-5-chlorobenzo[d]oxazole 
• 1019-90-5 5-chloro-2-phenyl-1,3-benzoxazole 
• 27383-92-2 methyl 5-chloro-1,3-benzoxazole-2-carboxylate 
• 49559-65-1 5-chloro-benzooxazole-2-carboxylic acid 
• 1258619-22-5 2-(3-phenyl-n-propyl)-5-chlorobenzo[d]oxazole 
• 1268070-58-1 4-(benzoxazol-5-yl)-N,N-dimethylbenzenamine 
• 1268070-55-8 1-(4-(benzoxazol-5-yl)phenyl)ethanone 
• 1268070-42-3 1-(4-(2-phenylbenzo[d]oxazol-5-yl)phenyl)ethanone 

Relevant articles and documents

An efficient synthesis of benzoxazoles using silica-supported tin exchanged silicotungstic acid catalyst

An efficient method for the preparation of benzoxazoles by reacting aminophenols with orthoesters in the presence of silica-supported tin exchanged silicotungstic acid catalyst under mild conditions with high yield and selectivity is demonstrated. The catalysts were characterized by FT-IR and pyridine adsorbed FT-IR. The catalyst exhibited consistent activity upon recycling and is highly active compared to other catalysts. The role of Lewis acidity of the catalysts and plausible reaction mechanism is presented.

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

Cu-Catalyzed Direct C-P Bond Formation through Dehydrogenative Cross-Coupling Reactions between Azoles and Dialkyl Phosphites

A direct dehydrogenative cross-coupling of azoles [C(sp2)-H] with dialkyl phosphites [P(O)-H] to access 2-phosphonated azoles using Cu(I)/Cu(II) as catalyst and K2S2O8/di-tert-butylperoxide as oxidant has been achieved. A remarkable advantage over reported procedures includes that oxazoles, imidazoles, benz(ox/othi/imid)azoles, and indole are found to react under optimized reaction conditions to provide corresponding adducts in high yields. The mechanistic insight of cross-coupling was obtained by deuterium kinetic isotope effect studies.