172215-91-7

Basic information

• Product Name: 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE
• Synonyms: 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE;Benzenamine, 3-bromo-4-(trifluoromethyl)-
• CAS NO: 172215-91-7
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.0205096
• Mol File: 172215-91-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108℃ (ligroine )
• Boiling Point: 244.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.697±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.69±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE(172215-91-7)
• EPA Substance Registry System: 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE(172215-91-7)

Safety Data

• Hazardous Substances Data: 172215-91-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-(trifluoromethyl)aniline is a chemical compound with the molecular formula C7H5BrF3N. 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE is a derivative of aniline, containing a bromine atom and a trifluoromethyl group attached to the benzene ring. It is used in the synthesis of various pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. 3-Bromo-4-(trifluoromethyl)aniline is known for its strong nucleophilic properties and is commonly used as a building block in organic synthesis. 3-BROMO-4-(TRIFLUOROMETHYL)ANILINE is also used as an intermediate in the production of specialty chemicals and is available for purchase from various chemical suppliers for research and industrial purposes.

Upstream product

• 875238-74-7 2-bromo-4-nitro-1-(trifluoromethyl)benzene 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 887144-94-7 Togni's reagent II 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 1373233-07-8 5-bromo-2-iodo-4-(trifluoromethyl)aniline 
• 1193384-47-2 5-(methylthio)-2-nitro-4-(trifluoromethyl)benzenamine 

Relevant articles and documents

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.