17337-68-7

Basic information

• Product Name: N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide
• Synonyms: N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide
• CAS NO: 17337-68-7
• Molecular Weight: 526.633
• Mol File: 17337-68-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide(17337-68-7)
• EPA Substance Registry System: N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide(17337-68-7)

Safety Data

• Hazardous Substances Data: 17337-68-7(Hazardous Substances Data)

Upstream product

• 5241-56-5 benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate 
• 2389-60-8 Z-Lys(Boc)-OH 
• 5241-58-7 L-Phenylalanine amide 
• 4677-76-3 (S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoic acid 2,4,5-trichloro-phenyl ester 

Downstream Products

• 736992-21-5 D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide 
• 97327-31-6 Glp-Lys-gPhe-(S)-mAla-Pro-OH 
• 97327-31-6 Glp-Lys-gPhe-(R)-mAla-Pro-OH 
• 97327-28-1 Glp-Lys(Boc)-gPhe-(S)-mAla-Pro-OtBu 
• 97327-28-1 Glp-Lys(Boc)-gPhe-(R)-mAla-Pro-OtBu 
• 97327-26-9 Glp-Lys(Boc)-gPhe-H*HCl 
• 81085-78-1 Glp-Lys(Boc)-Phe-NH₂ 
• 17337-86-9 H-Lys(Boc)Phe-NH₂ 

Relevant articles and documents

Synthesis, Resolution, and Assignment of Configuration of Potent Hypotensive Retro-inverso Bradykinin Potentiating Peptide 5a(BPP5a) Analogues

The effect on the the biological activity of an inverted amide group as an isosteric replacement for the Phe-Ala scissile bond of the BPP5a analogue 3>BPP5a has been studied.The synthesis of the retro-inverso pentapeptide 3,(R,S)-mAla4>BPP5a has been carried out in solution by coupling the pseudopeptide epimer HO-(R,S)-mAla-Pro-OBut to Glp-Lys(Boc)-gPhe-H.HCl, separation and identification of the resulting diastereomers 2(Boc),gPhe3,(S)-mAla4,Pro5-OBut>BPP5a and 2(Boc),gPhe3,(R)-mAla4,Pro5-OBut>BPP5a, and finally acidolytic cleavage. 3,(S)-mAla4>BPP5a, a moderate inhibitor of angiotensin converting enzyme (ACE) in vitro (I50=14 x 1E-5), was obtained and proved to be more potent than BPP5a as a hypotensive in normotensive rats without manifesting the bradykinin potentiating action of the natural peptide.