1735-84-8

Basic information

• Product Name: 3-Chloro-2,4,5,6-tetrafluoropyridine
• Synonyms: 2-CHLORO-2,4,5,6-TETRAFLUOROPYRIDINE;3-CHLORO-TETRAFLUOROPYRIDINE;3-CHLORO-2,4,5,6-TETRAFLUOROPYRIDINE;3-CHLORO-2,4,5,6-TETRAFLUOROPYRIDINE, 98 %;3-Chloroperfluoropyridine.;3-Chloro-2,4,5,6-tetrafluoropyridine 98%;2,4,5,6-TETRAFLUORO-3-CHLOROPYRIDINE;2,3,4,6-Tetrafluoro-5-chloropyridine
• CAS NO: 1735-84-8
• Molecular Formula: C₅ClF₄N
• Molecular Weight: 185.51
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;Chloropyridines;Fluoropyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 1735-84-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 118-121 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colourless liquid
• Density: 1.609 g/mL at 25 °C(lit.)
• Vapor Pressure: 217mmHg at 25°C
• Refractive Index: n20/D 1.436(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -11.94±0.28(Predicted)
• BRN: 475873
• CAS DataBase Reference: 3-Chloro-2,4,5,6-tetrafluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2,4,5,6-tetrafluoropyridine(1735-84-8)
• EPA Substance Registry System: 3-Chloro-2,4,5,6-tetrafluoropyridine(1735-84-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1735-84-8(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

General Description

3-Chloro-2,4,5,6-tetrafluoropyridine (3-chlorotetrafluoropyridine) is a fluoropyridine derivative. Its quantum mechanical calculations of energies, geometries and vibrational wave numbers have been performed by DFT level of theory. The interpretation of its FT-IR and FT-Raman spectra have been reported. It forms corresponding organo-zinc compound by reacting with zinc. 3-Chlorotetrafluoropyridine reacts with tris(diethylamino)phosphine (P(NEt)3) in the presence of a proton donor to form product with fluorine replaced by hydrogen at position 4.

InChI:InChI=1/C5H3F7O/c1-3(2(6)13,4(7,8)9)5(10,11)12/h1H3

Upstream product

• 700-16-3 Pentafluoropyridine 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 7789-23-3 potassium fluoride 
• 117204-89-4 3-chloro-2,4,5,6-tetrafluoro-1-azabicyclo<2.2.0>hexa-2,5-diene 
• 110-89-4 piperidine 

Downstream Products

• 72695-42-2 3-cyclohexyltetrafluoropyridine 
• 1541-20-4 bicyclohexyl-2,2'-diene 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 
• 2879-42-7 3-chloro-2,5,6-trifluoro-pyridine 
• 1592-34-3 2,3-diethoxybutane 
• 858860-03-4 2,5,6-trifluoro-4-methoxy-nicotinic acid benzyl ester 
• 858860-02-3 2,3,6-trifluoro-4-methoxypyridine 
• 1059628-50-0 5-chloro-3-fluoro-4-(2-fluorophenoxy)-6-methoxy-2-(morpholin-1-yl)pyridine 
• 3512-18-3 2,3,6-trifluoropyridine 
• 552322-79-9 trans-[NiCl(2,4,5,6-tetrafluoropyridin-3-yl)(P(cyclohexyl)3)2] 
• 52026-99-0 3,4-dichloro-2,5,6-trifluoropyridinev 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 351531-60-7 4,5-dibromo-2-(3-chloro-2,5,6-trifluoro-pyridin-4-yloxy)-phenol 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

METHOD FOR PRODUCING A COMPOUND CONTAINING FLUORINE VIA FLUORINE-HALOGEN EXCHANGE BY SPECIAL POLYAMINO PHOSPHAZENE CATALYSTS

The invention relates to a method for producing compounds containing fluorine by reacting a compound, which contains hydrogen that can be exchanged for fluorine, with a fluoride or with a mixture of fluorides of general formula (I): MeF, wherein Me represents an alkaline earth metal ion, an NH4+ ion or an alkali metal ion, in the presence or absence of a solvent at a temperature ranging from 60 to 260 °C. The invention is characterized in that the reaction is carried out in the presence of a compound or of a mixture of compounds of general formula (IIa) and/or (IIb), whereby X1 and/or X2 and/or X3, independent of one another, have groups of formula (llc) or other groups cited in the claims.

POLYHALOAROMATIC EQUILIBRATIONS

Chromium oxide is a good catalyst for scrambling halogens among polyhaloaromatic compounds.Chloropentafluorobenzene and bromopentafluorobenzene disproportionate to hexafluorobenzene and the respective tetrafluorodihalobenzenes.Pentachloro- and pentafluoropyridines produce pyridines with intermediate numbers of both types of halogens.Cyano, trifluoromethyl and a single hydrogen can be present on the aromatic rings without interfering with the chemistry.