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1738-25-6

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1738-25-6 Usage

Chemical Properties

clear colorless liquid

Uses

Different sources of media describe the Uses of 1738-25-6 differently. You can refer to the following data:
1. 3- Dimethylaminopropionitrile is used as a solvent, dielectric fluid, and an intermediate.
2. 3-(Dimethylamino)propionitrile has been used:to initiate the organic polymerization during the synthesis of class I hybrid poly(N-isopropylacrylamide)/silica hydrogelsin preparation of cysteine modifying agents based on the solvatochromic fluorophore 4-N,N-dimethylamino-1,8-naphthalimide (4-DMN)

Production Methods

3-Dimethylaminopropionitrile is derived from heating barium ethyl sulfate and KCN with subsequent distillation.

General Description

Colorless liquid. Mp: -44.3°C; bp: 171-172°C. Density 0.87 g cm-3 at 20°C). Water-soluble. Used in the manufacture of polyurethane foam. Excessive exposure leads to urologic and neurologic disorders.

Reactivity Profile

Dimethylaminopropionitrile is combustible but non-flammable (flash point > 140°F), reacts with oxidizing agents (Hazardous Chemicals Desk Reference, p. 426 (1987)). Reacts violently with LIAlH4, a strong reducing agent. Emits toxic oxides of nitrogen and cyanide fumes when heated to decomposition.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx and CN-. See also NITRILES.

Check Digit Verification of cas no

The CAS Registry Mumber 1738-25-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1738-25:
(6*1)+(5*7)+(4*3)+(3*8)+(2*2)+(1*5)=86
86 % 10 = 6
So 1738-25-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N2/c1-7(2)5-3-4-6/h3,5H2,1-2H3/p+1

1738-25-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Dimethylaminopropionitrile

1.2 Other means of identification

Product number -
Other names 2-DIMETHYLAMINOETHYL CYANIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1738-25-6 SDS

1738-25-6Relevant articles and documents

Addition of secondary amines to α,β-unsaturated carbonyl compounds and nitrites by using microstructured reactors

Loewe,Hessel,Lob,Hubbard

, p. 1144 - 1152 (2006)

Several additions of amines to α,β-unsaturated carbonyl compounds (Michael additions) were performed in a continuous-flow microstructured reactor rig and compared to the respective batch reaction. Dimethylamine/diethylamine/piperidine and acrylic acid ethyl ester/acrylonitrile were employed as two sets of reactants, giving six reactions. Some of these reactions are highly exothermal. Using the traditional batch procedure the olefin must be added quite slowly to the diluted amine to ensure temperature control and safe operation; especially this is necessary for the addition of dimethylamine (40 mass % aqueous solution) to acrylonitrile. Good yields (>85%) are achieved in this way; however, processing time is very long (17-25 h). To reveal the intrinsic kinetic potential and thus to accelerate these reactions, the reactants were mixed in a continuous-flow microstructured reactor rig which allows rapid mixing and efficient removal of the reaction heat. In this way, reaction time was decreased to a few seconds up to about half an hour, which is a change by 2 orders of magnitude. While the yields achieved with the continuous-flow microstructured reactor rig matched those for the batch procedure, the space-time yields for the microflow processing are much higher, in the best case by a factor of about 650.

Decarboxylation reactions. III. Reaction of N,N' and N,O linked methylene compounds with carboxylic acids

Sekiya,Matsuda,Ito

, p. 1579 - 1585 (1975)

-

Insights into Thiourea-Based Bifunctional Catalysts for Efficient Conversion of CO2to Cyclic Carbonates

Li, Zhuo-Qun,Zhang, Yao-Yao,Zheng, Yu-Jia,Li, Bo,Wu, Guang-Peng

, p. 3145 - 3155 (2022/02/14)

The bifunctional thiourea catalyst system with both electrophilic and nucleophilic centers has been certified to be effective for fixing CO2 under mild reaction conditions; however, many questions remain, especially concerning the relationship between str

Practical preparation of trimethoprim: A classical antibacterial agent

Ji, Ya-Fei,Jiang, Jian-An,Liu, Hong-Wei,Liao, Dao-Hua,Wei, Xian-Yong

supporting information, p. 1517 - 1522 (2013/05/22)

An efficient, simple, and mild preparation of the classical antibacterial agent trimethoprim (1) was achieved in 85% overall yield from 3,4,5-trimethoxybenzaldehyde (2). First, the addition of propenenitrile (3) with dimethylamine almost quantitatively afforded 3-dimethylaminopropanenitrile (7). Then, by condensation of 7 with 2 as well as the continuous replacement of 3-dimethylamino group with aniline in situ, the key intermediate 3-anilino-2-(3,4,5-trimethoxybenzyl)propenenitrile (9) was obtained in an excellent yield of 91% with a one-pot procedure. Finally, the cyclization of 9 with guanidine nitrate furnished 1 in yields as good as 95% in the presence of the excessive sodium methoxide. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

PROCESS FOR THE PREPARATION OF AMINONITRILE AND DIAMINE, AND CORRESPONDING DEVICES

-

Page/Page column 6, (2013/03/26)

The present invention relates to a continuous process for the preparation of an aminonitrile comprising the stages of: a) formation of the aminonitrile by reaction between an alkenyl nitrile, mixed with aminonitrile, and a monoamine introduced in molar excess with respect to the alkenyl nitrile; b) separation of the unreacted monoamine and the aminonitrile; c) reaction between the monoamine separated during stage b) and all or part of the alkenyl nitriie in order to form a mixture of aminonitrile and of unreacted alkenyl nitrile, with the alkenyl nitrile being introduced in molar excess with respect to the said monoamine; d) transfer of the mixture of aminonitrile and alkenyl nitrile resulting from stage c) to the reaction of stage a), e) in the case where only a portion of the alkenyl nitrile is introduced during stage c), introduction of the remaining molar amount of alkenyl nitrile into the mixture of stage d); the total molar amount of alkenyl nitrile introduced during stages c) and e) being equal to the molar amount of monoamine introduced during stage a). The present invention also relates to a process for the preparation of diamine comprising the continuous preparation of aminonitrile. The invention also relates to the devices corresponding to these processes.

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