173945-01-2

Basic information

• Product Name: 2-Pyrimidinamine, N-(2-nitrophenyl)-
• CAS NO: 173945-01-2
• Molecular Formula: C10H8N4O2
• Molecular Weight: 216.199
• Mol File: 173945-01-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Pyrimidinamine, N-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, N-(2-nitrophenyl)-(173945-01-2)
• EPA Substance Registry System: 2-Pyrimidinamine, N-(2-nitrophenyl)-(173945-01-2)

Safety Data

• Hazardous Substances Data: 173945-01-2(Hazardous Substances Data)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 57356-49-7 phenyl-pyrimidin-2-yl-amine 
• 609-73-4 o-nitroiodobenzene 
• 110-86-1 pyridine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 88-74-4 2-nitro-aniline 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.

Palladium(II)-catalyzed, heteroatom-directed, regioselective C-H nitration of anilines using pyrimidine as a removable directing group

A new palladium-catalyzed, heteroatom-directed strategy for C-H nitration of anilines is described. This C-H functionalization reaction is highly ortho-selective and results in very good yields. The highlight of the work is the use of pyrimidine as the removable directing group. This approach constitutes one of the rare methods of ortho-nitration of anilines, a reaction that is normally very difficult to achieve via traditional approaches.

CCK OR GASTRIN MODULATING 5-HETEROCYCLIC-1, 5 BENZODIAZEPINES

Compounds of general formula (I) and physiologically salts thereof, processes for their preparation and their use as modulators of the effects of gastrin and CCK.