17400-34-9

Basic information

• Product Name: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE
• Synonyms: BENZYL N-(3-AMINOPROPYL)CARBAMATE HYDROCHLORIDE;TIMTEC-BB SBB003190;N-(3-AMINOPROPYL)CARBAMIC ACID BENZYL ESTER HYDROCHLORIDE;N-1-Z-1,3-DIAMINOPROPANE HCL;N-1-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE;N1-BENZYLOXYCARBONYL-1,3-DIAMINOPROPANE HYDROCHLORIDE;N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE;N-CBZ-1,3-DIAMINOPROPANE HYDROCHLORIDE
• CAS NO: 17400-34-9
• Molecular Formula: C₁₁H₁₆N₂O₂*ClH
• Molecular Weight: 244.72
• Product Categories: Monoprotected Diaminoalkanes;N-Cbz-diaminoalkanes
• Mol File: 17400-34-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 185-189 °C
• Boiling Point: 396.6 °C at 760 mmHg
• Flash Point: 193.7 °C
• Appearance: White/Crystalline Solid
• Density: 1.109g/cm³
• Vapor Pressure: 1.11E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in water
• Sensitive: Hygroscopic
• BRN: 4725495
• CAS DataBase Reference: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(17400-34-9)
• EPA Substance Registry System: N-CARBOBENZOXY-1,3-DIAMINOPROPANE HYDROCHLORIDE(17400-34-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 17400-34-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C11H16N2O2.ClH/c12-7-4-8-13-11(14)15-9-10-5-2-1-3-6-10;/h1-3,5-6H,4,7-9,12H2,(H,13,14);1H

Upstream product

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• 177489-83-7 benzyl (3-azidopropyl)carbamate 
• 134307-72-5 2-(((benzyloxy)carbonyl)amino)ethyl 1-methanesulfonate 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 18807-68-6 N,N'-Dicarbobenzoxy-1,3-diaminopropan 

Downstream Products

• 46922-93-4 Carbobenzoxy-3-aminopropylcarbaminsaeure 
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• 88130-46-5 N-carbobenzoxy-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 86778-94-1 N-(4-phenylbutyryl)-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-96-8 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methylphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-97-9 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyltyrosine 3-(carbobenzoxyamino)propylamide 
• 86787-33-9 N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine 3-(carbobenzoxyamino)propylamide 
• 88105-89-9 N-(4-phenylbutyryl)-L-prolyl-L-phenylalanine 3-(carbobenzoxyamino)propylamide 
• 89450-69-1 N-<3-(1-uracilyl)propyl>-N'-carbobenzoxytrimethylenediamine hydrobromide 
• 88105-58-2 N-carbobenzoxy-L-prolyl-L-phenylalanine 3-(carbobenzoxyamino)propylamide 
• 109-76-2 Trimethylenediamine 
• 17415-89-3 N'-(p-Toluolsulfonyl)-N-benzyloxycarbonyl-1,3-diamino-propan 
• 319481-14-6 N-{5-O-[3-(Benzyloxycarbonylamino)propylcarbamoyl]-2,3-O-isopropylidene-β-D-ribofuranosyl}-3-(tert-butoxycarbonylamino)malonamide 
• 872315-98-5 {3-[(1S,2R)-2-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-1-(2,3-dihydro-indole-1-carbonyl)-2-hydroxy-ethylamino]-propyl}-carbamic acid benzyl ester 

Relevant articles and documents

Yohimbine derivatives and use thereof

Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α2c-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an α2c adrenergic receptor mediated condition or disorder, and for antagonizing activity of an α2c adrenergic receptor are also disclosed.

SYNTHESIS OF 1,3-DIAMINES

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