175453-07-3

Basic information

• Product Name: (S)-N-Fmoc-(3-Pyridyl)alanine
• Synonyms: (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PYRIDIN-3-YL-PROPIONIC ACID;(S)-N-FMOC-(3-PYRIDYL)ALANINE;RARECHEM AK ML 0095;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-3-(3-PYRIDYL)-L-ALANINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-3-(3-PYRIDYL)-L-ALANINE;N-(9-FLUORENYLMETHOXYCARBONYL)-3-PYRIDYL-L-ALANINE;N-ALPHA-FMOC-BETA-(3-PYRIDYL)-L-ALANINE;FMOC-(S)-2-AMINO-3-(3'-PYRIDYL)PROPANOIC ACID
• CAS NO: 175453-07-3
• Molecular Formula: C23H20N2O4
• Molecular Weight: 388.42
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Unusual Amino Acids;a-amino
• Mol File: 175453-07-3.mol

Chemical Properties

• Melting Point: 155.3 °C
• Boiling Point: 514.13°C (rough estimate)
• Flash Point: 344.3 °C
• Appearance: white to off-white crystalline powder
• Density: 1.2692 (rough estimate)
• Vapor Pressure: 1.5E-17mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: 2-8°C
• PKA: 3.32±0.10(Predicted)
• BRN: 9154190
• CAS DataBase Reference: (S)-N-Fmoc-(3-Pyridyl)alanine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Fmoc-(3-Pyridyl)alanine(175453-07-3)
• EPA Substance Registry System: (S)-N-Fmoc-(3-Pyridyl)alanine(175453-07-3)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 175453-07-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(S)-N-Fmoc-(3-Pyridyl)alanine is used as a building block for the synthesis of various complex organic molecules. Its unique structure allows for the creation of a wide range of compounds with diverse applications in different industries.
Used in Peptide Chemistry:
In peptide chemistry, (S)-N-Fmoc-(3-Pyridyl)alanine is utilized as a key component in the development of novel peptides. Its incorporation into peptide sequences can lead to the discovery of new bioactive molecules with potential therapeutic applications.
Used in Pharmaceutical Industry:
(S)-N-Fmoc-(3-Pyridyl)alanine is used as a starting material for the synthesis of drug candidates. Its unique properties make it a valuable asset in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Research and Development:
In the research and development sector, (S)-N-Fmoc-(3-Pyridyl)alanine is employed as a tool to study the structure and function of various biological molecules. Its use in this context can contribute to a better understanding of molecular interactions and the development of targeted therapies.
Overall, (S)-N-Fmoc-(3-Pyridyl)alanine is a versatile compound with a wide range of applications across different industries, including chemical synthesis, peptide chemistry, pharmaceuticals, and research and development. Its unique properties and potential uses make it an important compound for further exploration and development.

InChI:InChI=1/C23H20N2O4/c26-22(27)21(12-15-6-5-11-24-13-15)25-23(28)29-14-20-18-9-3-1-7-16(18)17-8-2-4-10-19(17)20/h1-11,13,20-21H,12,14H2,(H,25,28)(H,26,27)/t21-/m0/s1

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 102913-22-4 (4Z)-2-methyl-4((pyridin-3-yl)methylene)oxazol-5(4H)-one 
• 170092-30-5 N-acetyl-(β-3-pyridyl)-DL-alanine 
• 1397697-66-3 N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester 
• 746672-88-8 C₂₃H₂₀N₂O₄ 
• 17470-24-5 2-amino-3-(pyridin-3-yl)propanoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 923972-32-1 (S)-2-((S)-2-(3-((R)-1-(4-bromophenyl)ethyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid 
• 923972-28-5 (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid 
• 1610523-73-3 HO-Leu-N-Me-Val-D-Leu-D-3-(3-pyridyl)Ala-3,3-diphenyl-D-Ala-NH₂ 
• 934016-19-0 (4S)‐N‐(4‐((2S,5S,8R,11R)‐2‐(((R)‐1‐(((S)‐1‐(((S)‐1‐((S)‐2‐(((R)‐1‐amino‐1‐oxopropan‐2‐yl)carbamoyl)pyrrolidin‐1‐yl)‐6‐(isopropylamino)‐1‐oxohexan‐2‐yl)amino)‐4‐methyl‐1‐oxopentan‐2‐yl)amino)‐1‐oxo‐3‐(4‐ureidophenyl)propan‐2‐yl)carbamoyl)‐11‐(4‐chlorobenzyl)‐5‐(hydroxymethyl)‐14‐((naphthalen‐2‐yl)methyl)‐4,7,10,13,16‐pentaoxo‐8‐(pyridin‐3‐ylmethyl)‐3,6,9,12,15‐pentaazaheptadecyl)phenyl)‐2,6‐dioxohexahydropyrimidine‐4‐carboxamide acetate 

Relevant articles and documents

Chemoenzymatic routes to enantiomerically pure 2-azatyrosine and 2-, 3- and 4-pyridylalanine derivatives

Enantiomerically pure 2-, 3- or 4-pyridylalanine (pya) and 2-azatyrosine (azatyr) are known to present various biological activities. After incorporation into appropriate peptide sequences, these heterocyclic non natural α-amino acids could behave as new substrates or inhibitors of elastase from Pseudomonas aeruginosa. This enzyme is known to be involved in nosocomial infections and infections related to the cystic fibrosis disease. New efficient chemoenzymatic preparations of those compounds using α-chymotrypsin (α-CT) are presented. Springer-Verlag 2011.