17585-59-0

Basic information

• Product Name: L-Aspartic acid hydrochloride
• Synonyms: L-ASPARTIC ACID HYDROCHLORIDE SOLUTION;L-Aspartic acid hydrochloride;L-Aspartic acid solution hydrochloride;(S)-2-AMinosuccinic acid hydrochloride;(2S)-2-aMinobutanedioic acid hydrochloride
• CAS NO: 17585-59-0
• Molecular Formula: C₄H₇NO₄*ClH
• Molecular Weight: 169.56
• Product Categories: A;Amino Acids, Peptides and Proteins;Amino AcidsAlphabetic;AR to AZ;Life Sciences Standards
• Mol File: 17585-59-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 288.6 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Vapor Pressure: 0.000586mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-Aspartic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Aspartic acid hydrochloride(17585-59-0)
• EPA Substance Registry System: L-Aspartic acid hydrochloride(17585-59-0)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1789 8/PG 3
• WGK Germany: 1
• F: 10
• Hazardous Substances Data: 17585-59-0(Hazardous Substances Data)

Usage

General Description

L-Aspartic acid hydrochloride, or aspartate hydrochloride, is a crystalline solid compound derived from the amino acid aspartic acid. It is a salt form of aspartic acid in which the carboxyl group of the acid has been neutralized by a positively charged hydrochloric acid. L-Aspartic acid hydrochloride is commonly used as a food additive and a nutritional supplement due to its role in protein synthesis and metabolism. It is also used in the pharmaceutical industry as a component in the synthesis of certain drugs. L-Aspartic acid hydrochloride is generally considered safe for consumption in regulated amounts but should be used with caution by individuals with kidney or liver impairment.

InChI:InChI=1/C4H7NO4.ClH/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);1H/t2-;/m0./s1

Upstream product

• 70-47-3 L-asparagine 
• 1319113-54-6 (3RS,6S)-3-[di(methoxycarbonyl)methyl]-1,6-trimethylene-2,5-piperazinedione 
• 1676-90-0 Boc-Asp(OtBu)-OH 
• 56-84-8 L-Aspartic acid 

Downstream Products

• 97-67-6 (S)-Malic acid 
• 136703-59-8 (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester 
• 6384-18-5 L-Aspartic acid dimethyl ester 

Relevant articles and documents

A comparative study of two polymorphs of l-aspartic acid hydrochloride

Two polymorphs of l-aspartic acid hydrochloride, C4H 8NO4+ Cl-, were obtained from the same aqueous solution. Their crystal structures have been determined from single-crystal data collected at 100 K. The crystal structures revealed three- and two-dimensional hydrogen-bonding networks for the triclinic and orthorhombic polymorphs, respectively. The cations and anions are connected to one another via N-H...Cl and O-H...Cl interactions and form alternating cation-anion layer-like structures. The two polymorphs share common structural features; however, the conformations of the l-aspartate cations and the crystal packings are different. Furthermore, the molecular packing of the orthorhombic polymorph contains more interesting interactions which seems to be a favourable factor for more efficient charge transfer within the crystal.

3-Triphenylphosphonio-2,5-piperazinediones as new chiral glycine cation equivalents

3-Triphenylphosphonio-2,5-piperazinediones were effectively synthesized from homochiral valine or proline via Boc-Val-Gly-OMe, Boc-Pro-Gly-OMe or Cbz-Pro-Gly-OMe. Retention of configuration of the primary stereogenic center of the valine and proline moieties was observed. Diastereoselective nucleophilic substitution of the triphenylphosphonium group in 2,5-piperazinediones with S-, N-, P- and C-nucleophiles was observed. The configuration of the substitution products was assigned either by their hydrolysis and decarboxylation or based on the analysis of the H-C(3)-N-H coupling constants of 3-substituted-2,5- piperazinediones derived from proline. The trans-stereoselectivity was predominant in reactions of 3-triphenylphosphonio-1,6-trimethylene-2,5- piperazinediones with the nucleophiles investigated. The stereodifferentiating ability of the proline moiety is much stronger than that of the valine unit and allowed nucleophilic α-functionalization of the glycine moiety with good to excellent diastereoselectivity.

Amino acid esters of phenols as prodrugs: Synthesis and stability of glycine, β-aspartic acid, and α-aspartic acid esters of p-acetamidophenol

-