175888-75-2Relevant articles and documents
Design of an integrated process of chromatography, crystallization and racemization for the resolution of 2′,6′-pipecoloxylidide (PPX)
Von Langermann, Jan,Kaspereit, Malte,Shakeri, Mozaffar,Lorenz, Heike,Hedberg, Martin,Jones, Matthew J.,Larson, Kerstin,Herschend, Bjoern,Arnell, Robert,Temmel, Erik,Baeckvall, Jan-Erling,Kienle, Achim,Seidel-Morgenstern, Andreas
experimental part, p. 343 - 352 (2012/06/18)
An integrated process for the chiral separation of the industrially relevant substance 2′,6′-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.
