17614-10-7

Basic information

• Product Name: (1-Methylethyl)carbaMic Acid Phenyl Ester
• Synonyms: (1-Methylethyl)carbaMic Acid Phenyl Ester;N-(1-Methylethyl)carbaMic Acid Phenyl Ester;NSC 190576;PhenylN-(propan-2-yl)carbamate
• CAS NO: 17614-10-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179
• Product Categories: Aromatics;Intermediates
• Mol File: 17614-10-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 246.1°Cat760mmHg
• Flash Point: 102.7°C
• Appearance: /
• Density: 1.058g/cm³
• Vapor Pressure: 0.0276mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: (1-Methylethyl)carbaMic Acid Phenyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Methylethyl)carbaMic Acid Phenyl Ester(17614-10-7)
• EPA Substance Registry System: (1-Methylethyl)carbaMic Acid Phenyl Ester(17614-10-7)

Safety Data

• Hazardous Substances Data: 17614-10-7(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of Torsemide metabolites.

InChI:InChI=1/C10H13NO2/c1-8(2)11-10(12)13-9-6-4-3-5-7-9/h3-8H,1-2H3,(H,11,12)

Upstream product

• 35180-03-1 chloromethyl phenyl carbonate 
• 75-31-0 isopropylamine 
• 102-09-0 bis(phenyl) carbonate 
• 1885-14-9 phenyl chloroformate 
• 118-55-8 phenyl Salicylate 
• 1795-48-8 Isopropyl isocyanate 
• 108-95-2 phenol 

Downstream Products

• 5673-38-1 N-(isopropylcarbamoyl)-4-methylbenzenesulfonamide 
• 2281-78-9 4-chloro-N-(isopropylcarbamoyl)benzenesulfonamide 
• 81787-62-4 o-((trimethylsilyl)ethynyl)phenol 
• 56211-40-6 torasemide 
• 28177-54-0 2,6-diiodo-phenol 
• 899427-44-2 2,6-bis(trimethylsilyl)phenyl isopropylcarbamate 
• 899427-38-4 2-hydroxyphenylmethyl-6-iodophenyl isopropylcarbamate 
• 899427-47-5 2,6-diiodophenyl isopropylcarbamate 
• 129112-26-1 2-iodophenyltrifluoromethanesulfonic acid 
• 533-58-4 2-Iodophenol 
• 864908-76-9 2-iodophenyl isopropylcarbamate 

Relevant articles and documents

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A facile synthesis of sulfonylureas: Via water assisted preparation of carbamates

A novel and simple approach to the synthesis of sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequently reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous:organic (H2O:THF, 90:10) medium at room temperature to produce carbamates that paved a straightforward route to sulfonylureas after reaction with sulfonamides. The above process avoided traditional multistep protocols and the use of hazardous, irritant, toxic and moisture sensitive reagents such as phosgene, isocyanates and/or chloroformates.

Facile preparation of 2-iodophenyl trifluoromethanesulfonates: Superior aryne precursors

A comparative study of 3-methoxyaryne precursors revealed 2-iodo-3-methoxyphenyl triflate as the most effective in nonpolar solvent. Use of Hoppe's N-isopropyl carbamate allows for the systematic preparation of a variety of 2-iodophenyl triflates via a directed ortho-lithiation-iodination- decarbamation sequence. These steps are possible without isolation of the intermediate iodophenyl carbamates. Georg Thieme Verlag Stuttgart.