17672-27-4

Usage

Uses

Used in Organic Synthesis:
4-hydrazinylbenzonitrile is used as a building block in organic synthesis for the creation of a variety of compounds, including hydrazide derivatives, due to its reactive functional groups and structural properties.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-hydrazinylbenzonitrile is utilized as a precursor for the synthesis of drugs, leveraging its chemical reactivity to form new pharmaceutically active molecules.
Used in Pesticide and Herbicide Industries:
4-hydrazinylbenzonitrile is used as a potential pesticide and herbicide due to its bioactivity, indicating its potential use in controlling pests and unwanted plant growth in agricultural applications.
Used in Anti-tumor Research:
4-hydrazinylbenzonitrile is being investigated for its potential as an anti-tumor agent, suggesting its possible role in the development of treatments for cancer.
Used in Laboratory Research:
Due to its high purity and stability, 4-hydrazinylbenzonitrile is used as an important reagent in various laboratory research applications, facilitating experiments and the discovery of new chemical reactions and compounds.

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 2863-98-1 4-hydrazinobenzonitrile hydrochloride 

Downstream Products

• 99056-05-0 3-hydroxy-propionic acid-[N'-(4-cyano-phenyl)-hydrazide] 
• 70449-44-4 N-Trichloracetyl-α-(L-aspartyl)-hydrazid 
• 70449-64-8 N-Acetyl-α-L-aspartyl-hydrazid 
• 127123-03-9 ({2-{2-[2-(Bis-methoxycarbonylmethyl-amino)-5-methyl-phenoxy]-ethoxy}-4-[2-(4-cyano-phenyl)-5-(4-methanesulfonyl-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-phenyl}-methoxycarbonylmethyl-amino)-acetic acid methyl ester 
• 84223-51-8 5-Cyan-1-benzofuran-2-carbaldehyd-(4-cyanphenyl)hydrazon 
• 442520-03-8 4-(2,5-dioxo-2,5-dihydro-pyrrol-1-ylamino)-benzonitrile 
• 586353-21-1 1-(4-cyano-phenyl)-1,4,5,6-tetrahydro-1,2,6,7-tetraaza-as-indacene-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine

In this work, we developed a ligand- and base-free visible-light-mediated protocol for the photoredox syntheses of arylphosphonates and, for the first time, alkyl phosphonates. Zinc phthalocyanine-photocatalyzed Csp2-P and Csp3-P bond formations were efficiently achieved by reacting aryl/alkylhydrazines with trialkylphosphites in the presence of air serving as an abundant oxidant. The reaction conditions tolerated a wide variety of functional groups.

Synthesis method of oxalyl hydrazine ligands and application of oxalyl hydrazine ligands in C-N bond coupling reaction

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a synthesis method of oxalyl hydrazine ligands and application of the oxalyl hydrazine ligands to C-N coupling reaction. The invention provides a method for synthesizing oxalyl hydrazine ligands by taking hydrazine compounds and oxalyl chloride as raw materials. The method has the advantages that the raw materials are easy to obtain, the operation is simple, the post-treatment is easy, and the method is suitable for industrial large-scale production; furthermore, coupling of aryl iodide andhydrazine hydrate is realized by utilizing oxalyl hydrazine ligands, and aryl hydrazine is synthesized. The method is mild in reaction condition, safe, efficient and suitable for industrial production.

SUBSTITUTED SULFONYL HYDRAZIDES AS INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY

The present invention relates to substituted sulfonyl hydrazides that have the ability to inhibit lysine biosynthesis via the diaminopimelate pathway in certain organisms. As a result of this activity these compounds can be used in applications where inhibition of lysine biosynthesis is useful applications of this type include the use of the compound as herbicides and/or anti- bacterial agents.

Lewis Acid Catalyzed Annulation of Cyclopropane Carbaldehydes and Aryl Hydrazines: Construction of Tetrahydropyridazines and Application Toward a One-Pot Synthesis of Hexahydropyrrolo[1,2- b]pyridazines

In this report, a facile synthesis of tetrahydropyridazines via a Lewis acid catalyzed annulation reaction of cyclopropane carbaldehydes and aryl hydrazines has been demonstrated. Moreover, the generated tetrahydropyridazine further participated in a cycloaddition reaction with donor-acceptor cyclopropanes to furnish hexahydropyrrolo[1,2-b]pyridazines. We also performed these two steps in one pot in a consecutive manner. In addition, a monodecarboxylation reaction of hexahydropyrrolo[1,2-b]pyridazine was achieved with a good yield.

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Synthesis and Site-Specific Incorporation of Red-Shifted Azobenzene Amino Acids into Proteins

A series of red-shifted azobenzene amino acids were synthesized in moderate-to-excellent yields via a two-step procedure in which tyrosine derivatives were first oxidized to the corresponding quinonoidal spirolactones followed by ceric ammonium nitrate-catalyzed azo formation with the substituted phenylhydrazines. The resulting azobenzene-alanine derivatives exhibited efficient trans/cis photoswitching upon irradiation with a blue (448 nm) or green (530 nm) LED light. Moreover, nine superfolder green fluorescent protein (sfGFP) mutants carrying the azobenzene-alanine analogues were expressed in E. coli in good yields via amber codon suppression with an orthogonal tRNA/PylRS pair, and one of the mutants showed durable photoswitching with the LED light.

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

Regioselective radical arylation of anilines with arylhydrazines

Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivities, and anilines have been shown to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as phenolates under strongly basic conditions. Finally, radical arylation reactions of anilines and anilinium salts under various conditions have for the first time demonstrated that regioselectivity can also be controlled through the rearomatization step and that the addition of an aryl radical to a substituted benzene might even be reversible.

Pyrazolones derivatives

A pyrazolone derivative represented by general formula (I) or a salt thereof: STR1 [wherein one of X1 and X2 is STR2 (wherein A is a cyano group, a cyano C1-4 alkyl group, an amino group, an amino C1-4 alkyl group, an amidino group or a guanidino group, R1 and R2 are independently hydrogen atoms, halogen atoms, C1-6 alkyl groups or the like) or the like], the other of X1 and X2 is a C1-6 alkyl group, a C3-6 alkenyl group, an aryl C1-4 alkyl group or an aryl group, one of Y1 and Y2 is STR3 (wherein Q is an oxygen atom or a sulfur atom, Z1 is an oxygen atom, a --NR7 -- group or a --CHR7 -- group, Z2 is a cyclic C3-7 alkylene group, a C1-3 alkylene group, a --CH2 CO-- group or --CH2 CH2 CO-- group, Z3 is an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group or the like, Z4 is a C1-3 alkylene group, and Z5 is a carboxyl group or the like, and the other of Y1 and Y2 is a D-E- group [wherein E is a bond, a C1-4 alkylene group or a phenylene group, and D is a hydrogen atom, a C1-6 alkyl group or the like which has an inhibitory action on platelet aggregation and is useful as a preventive or therapeutic agent for various thrombotic diseases.

Fused imidazole and triazole derivatives as 5-HT1 receptor agonists

Compounds of formula (I) wherein F represents a Group of the formula (a) ; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; and the rest of the variables are defined in the specification are selective agoni